Solid phase N-hydroxysuccinimide reagents

Details Solid phase N-hydroxysuccinimide reagents Solid phase N-hydroxysuccinimide reagents

1987-08-10

1989-03-14

Lacey, David L.

Stock material or miscellaneous articles

Coated or structually defined flake, particle, cell, strand,...

Particulate matter

436 89, 436172, 525431, 525541, 528310, B32B 516

Patent

active

048123625

ABSTRACT:
A solid phase N-hydroxysuccinimide reagent having the general formula: ##STR1## where X is particulate silica gel or controlled pore glass; n=3-7; Y is either (CH.sub.2).sub.n' or (CH.sub.2).sub.n' --NH--CO--CH.sub.2 wherein n'=2-6; Z may be in the form of OCOR, OSO.sub.2 R and OCO.sub.2 R, and Z' may be either Z or OH, wherein R is a chromophore, fluorophore or electrophore capable of detection in chromatographic separation technology is disclosed. Also disclosed is the method for making compounds of this type and the method for using these compounds to identify and quantitate analytes having primary or secondary amine or thiol functionalities.

REFERENCES:
patent: 4199617 (1980-04-01), Vanderpool
patent: 4489055 (1984-12-01), Couvreur et al.
patent: 4568518 (1986-02-01), Wolfbeis et al.
patent: 4610966 (1986-09-01), Fuchs
patent: 4743561 (1988-05-01), Shoffar
patent: 4749430 (1988-06-01), Samuelson et al.
patent: 4769289 (1988-09-01), Kelly et al.

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