Solid phase multiple peptide synthesis

Details Solid phase multiple peptide synthesis Solid phase multiple peptide synthesis

1993-04-02

1994-02-15

Schofer, Joseph L.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525 541, 5253336, 525350, 525374, 525379, 530333, 530334, 530335, 530815, 530816, C08F 832, C08L 8900

Patent

active

052867897

ABSTRACT:
Methods and compositions are provided, where oligopeptides are produced on a transparent surface while retaining transparency by the cyclical addition of protected monomers. Reagents are specifically selected to allow for efficient reproducible addition, while maintaining transparency of the support. Linkers are provided which permit retention of the oligopeptide to the surface or release of the oligopeptide at completion of the preparation of the oligopeptide. The oligopeptide bound to the support finds use in diagnostic assays, as well as other application, while the free oligopeptides may be used in a variety of ways.

REFERENCES:
patent: 3875114 (1975-04-01), Swiger
patent: 3906031 (1975-09-01), Carpino
patent: 4315998 (1982-02-01), Neckers et al.
patent: 4914151 (1990-04-01), Mergler
patent: 4933410 (1990-06-01), Okrongly
patent: 4978724 (1990-12-01), Clark
patent: 5241012 (1993-08-01), Clark
Organic Chemistry 3rd Ed., Morrison & Boyd Allyn & Bacon (1973) pp. 456-457.
Merrifield, Solid Phase Synthesis 24 Agew. Chem. (Oct. 1985) at 749-892.
Giralt et al. (Par Resin) A New Polymeric Support . . . 37(10) Tetrahedron (1981) At 2007-10.
Jakubke, et al., Aminosauren, Peptide Proteine, (1982) Chapter 2.2.7, pp. 204-212, Verlag Chemie, Weinheim, Germany.
Nakagawa et al., "Synthesis of protected peptide segments and their assembly on a polymer-bound oxime: application to the synthesis of a peptide model for plasma apolipoprotein A-I," Chem. Abstracts, 98(13):107756b.
Mergler et al., "Peptide synthesis by a combination of solid-phase and solution methods. I. A new very acid-labile anchor group for the solid phase synthesis of fully protected fragments," Chem. Abstract, 110(11):95779n.
Shekhani et al., "Carboramidomethyl esters as useful handle in polystyrene-based peptide synthesis: cleavage of peptide with mercaptide," Tetrahedron Letters, 31(3):339-340 (1990).

Affiliated with

Also associated with

Rating

Solid phase multiple peptide synthesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Solid phase multiple peptide synthesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Solid phase multiple peptide synthesis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1207709