Solid phase biological diagnostic assay via visual observation a

Details Solid phase biological diagnostic assay via visual observation a Solid phase biological diagnostic assay via visual observation a

1986-08-20

1987-12-29

Rosen, Sam

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

422 56, 422 57, 435 4, 435 7, 435805, 435810, 436531, 436532, 436534, 436536, 436805, G01N 33546

Patent

active

047161230

ABSTRACT:
Methods and kits are set out having improved selectivity and improved sensitivity for use in field and home immunoassays. A specifically binding biomaterial is attached to a macroextensive surface of a plastic strip or the like. A biological substance which is a specific binding partner to a binding site of the specifically binding biomaterial is attached to each of a plurality of synthetic particles. The particles are of a preselected size, refractive index, or the like to enhance their visibility in accordance with the Mie scattering phenomenon. Testing is by either contacting the particles with the strips to obtain adherence of the particles to the strips, or by exposing strips having the particles already adhering to them to a solution containing either the specifically binding biomaterial or the biological substance, whereby the particles adherence to the strip is eliminated. A quick and accurate pregnancy test is one result of the invention.

REFERENCES:
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Bernard et al.--Clinical Chemistry, vol. 27 (1981), pp. 832-837.
Quash et al.--J. Immunol. Methods, vol. 22 (1978), pp. 165-174.
Grange et al.--J. Immunol. Methods, vol. 18 (1977), pp. 365-375.

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