Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1993-06-29
1995-05-09
Spiegel, Carol A.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
436501, 436524, 436527, 436531, 435970, 2502019, G01N 33543, G01J 120
Patent
active
054139392
ABSTRACT:
A solid-phase binding assay that measures interferometrically either antibodies or binding pair antigens bound to a spinning disc on which the complementary antigen or antibody has previously been coated in an alternating pattern of immunologically active and inactive spots. The spinning disc is inserted into one arm of a Mach-Zehnder interferometer and as the disc spins the bound and unbound spots pass one after another through the two light beams causing a periodic phase shift in the light. These phase modulated light beams are then recombined at a beam-splitter converting the phase modulation into an amplitude modulation. The two recombined beams then fall on a photodetector which converts the periodically varying optical power into a periodically varying electrical current whose amplitude is proportional to the amount of bound protein on the surface of the disc and whose modulation frequency is equal to the frequency with which the spots pass through the light beam. If the disc is spinning rapidly and there are many spots around the disc this signal frequency will be much higher than the frequency of the noise due to the disc wobble and the vibrations imparted to the interferometer by the spinning motor.
REFERENCES:
patent: Re33581 (1991-04-01), Nicoli et al.
patent: 3639558 (1972-02-01), Csizmas et al.
patent: 3823604 (1974-07-01), Burch et al.
patent: 3853467 (1974-12-01), Giaever
patent: 3854050 (1974-12-01), Peterson et al.
patent: 3926564 (1975-12-01), Giaever
patent: 3939350 (1976-02-01), Kronick et al.
patent: 3960451 (1976-06-01), Wirz et al.
patent: 3960488 (1976-06-01), Giaever
patent: 3960489 (1976-06-01), Giaever
patent: 3960490 (1976-06-01), Giaever
patent: 3960491 (1976-06-01), Giaever
patent: 3975238 (1976-08-01), Bean et al.
patent: 3979184 (1976-09-01), Giaever
patent: 3979509 (1976-09-01), Giaever
patent: 4011308 (1977-03-01), Giaever
patent: 4018886 (1977-04-01), Giaever
patent: 4030835 (1977-06-01), Firester et al.
patent: 4050895 (1977-09-01), Hardy et al.
patent: 4054646 (1977-10-01), Giaever
patent: 4090849 (1978-05-01), Healy et al.
patent: 4115535 (1978-09-01), Giaever
patent: 4172827 (1979-10-01), Giaever
patent: 4181501 (1980-01-01), Keese et al.
patent: 4223257 (1980-09-01), Miller
patent: 4321057 (1982-03-01), Buckles
patent: 4399099 (1983-08-01), Buckles
patent: 4451923 (1984-05-01), Hansch et al.
patent: 4487839 (1984-12-01), Kamentsky
patent: 4508832 (1985-04-01), Carter et al.
patent: 4521522 (1985-06-01), Lundstrom et al.
patent: 4537861 (1985-08-01), Elings et al.
patent: 4554088 (1985-11-01), Whitehead et al.
patent: 4558012 (1985-12-01), Nygren et al.
patent: 4608344 (1986-08-01), Carter et al.
patent: 4628037 (1986-12-01), Chagnon et al.
patent: 4647544 (1987-03-01), Nicoli et al.
patent: 4695392 (1987-09-01), Whitehead et al.
patent: 4695393 (1987-09-01), Whitehead et al.
patent: 4698302 (1987-10-01), Whitehead et al.
patent: 4818710 (1989-04-01), Sutherland et al.
patent: 4820649 (1989-04-01), Kawaguchi et al.
patent: 4844613 (1989-07-01), Batchelder
patent: 4876208 (1989-10-01), Gustafson et al.
patent: 4886761 (1989-12-01), Gustafson
patent: 4931384 (1990-06-01), Layton et al.
patent: 4932783 (1990-06-01), Kersey et al.
patent: 4940328 (1990-07-01), Hartman
patent: 4950074 (1990-08-01), Fabricius et al.
patent: 5089387 (1992-02-01), Tsay et al.
patent: 5096807 (1992-03-01), Leaback
patent: 5118608 (1992-06-01), Layton et al.
patent: 5120131 (1992-06-01), Lukosz
patent: 5126276 (1992-06-01), Fish et al.
patent: 5173747 (1992-12-01), Boiarski et al.
patent: 5196350 (1993-03-01), Backman et al.
patent: 5218419 (1993-06-01), Lipson et al.
patent: 5225887 (1993-07-01), Lipson et al.
Van Nostrand's Scientific Encyclopedia, seventh edition, (1989), pp. 1579-1580, "Interferometer".
Alex Abramovici et al., "LIGO: The Laser Interferometer Gravitational-Wave Observatory", Science, vol. 256, 17 Apr. 1992, pp. 325-333.
M. A. Butler, "Optical fiber hydrogen sensor", Appl. Phys. Lett. 45(10), 15 Nov. 1984, .COPYRGT.1984 American Institute of Physics, pp. 1007-1009.
"The Electronic Toolbox Part 1", Analytical Chemistry, vol. 57, No. 11, Sep. 1985, .COPYRGT.1985 American Chemical Society, pp. 1188A-1202A.
Allen Jimmy D.
Cobb Michael E.
Gustafson Eric K.
First Medical, Inc.
Spiegel Carol A.
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