Solid phase and combinatorial synthesis of benzodiazepine compou

Details Solid phase and combinatorial synthesis of benzodiazepine compou Solid phase and combinatorial synthesis of benzodiazepine compou

1992-09-14

1994-02-22

Pal, Asok

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Particulate or unit-dosage-article base

530334, 530337, 530345, A01N 102

Patent

active

052885143

ABSTRACT:
Methods, compositions, and devices for synthesis of therapeutically useful compounds. The invention provides a rapid approach for combinatorial synthesis and screening of libraries of derivatives of therapeutically important classes of compounds such as benzodiazepines, prostaglandins and .beta.-turn mimetics. In order to expediently synthesize a combinatorial library of derivatives based upon these core structures, general methodology for the solid phase synthesis of these derivatives is also provided. This disclosure thus also describes an important extension of solid phase synthesis methods to nonpolymeric organic compounds.

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