Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-03
1998-11-17
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514569, 514723, 514738, A61K 3147, A61K 3119, A61K 3108, A61K 31045
Patent
active
058377140
ABSTRACT:
This invention provides solid pharmaceutical dispersions comprising a poorly soluble drug substance, as SR48692 or naproxen, xylitol and Transcutol, and a method of preparing such dispersions comprising the steps of dissolving the poorly soluble drug substance in Transcutol and adding the solution to xylitol. The dispersions exhibit good pharmaceutical properties and reduced levels of impurities and degradation products.
REFERENCES:
patent: 5420141 (1995-05-01), Biogegrain et al.
Sirenius et al, J. Pharm. Sci., 66, No. 6, Jun. 1979.
Sheen et al, J. Pharm. Sci., 118, No. 2, 1995 (Abstract).
Laughlin Sharon
Rocco William
Alexander Michael D.
Bauman Mark P.
Sanofi
Spivack Phyllis G.
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