Solid pharmaceutical compositions comprising MSM and their produ

Details Solid pharmaceutical compositions comprising MSM and their produ Solid pharmaceutical compositions comprising MSM and their produ

1984-02-28

1986-02-04

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic nonactive ingredient containing other...

Aftertreated solid synthetic organic polymer

264117, 424 14, 424 16, 514951, 514960, A61K 3117, A61K 3110

Patent

active

045685479

ABSTRACT:
Methylsulfonylmethane (MSM) is useful as a tableting and granulating aid for pharmaceutically active agents, especially those which are unstable in the presence of moisture, mixtures therewith being or formable into free-flowing powders or granules which are readily compressible into tablets of improved properties. A preferred method of forming such powders or granules involves mixing the pharmaceutically active agent under substantially anhydrous conditions with molten MSM or with particulate solid MSM at its softening point, cooling the resultant mixture and, when the MSM was molten, forming the solidified melt into granules or a free flowing powder and thereafter, if desired, compressing the powder or granules into tablets.

REFERENCES:
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patent: 4296104 (1981-10-01), Herschler
patent: 4296130 (1981-10-01), Herschler
patent: 4447421 (1984-05-01), Klothen
patent: 4477469 (1984-10-01), Herschler

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