Solid pharmaceutical composition

Details Solid pharmaceutical composition Solid pharmaceutical composition

1992-05-21

1993-03-02

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Specially adapted for ruminant animal

424472, 424480, 424482, A23K 118

Patent

active

051907607

ABSTRACT:
A solid pharmaceutical composition for release of a biologically active substance into a desired aqueous environment, containing a core and an outer layer, said core comprising between 17 and 93% by weight of the biologically active substance, between 0.01 and 7% by weight of a water swellable polymer material and between 0 and 83% of one or more accessory ingredients, relative to the total weight of the core; and the outer layer comprising between 25 and 75% by weight of the biologically active substance, between 25 and 75% by weight of a material for enabling rapid dispersion of the outer layer into the aqueous environment and 0 to 50% by weight of one or more accessory ingredients, relative to the total weight of the outer layer. The composition is preferably formulated as a bolus for veterinary use.

REFERENCES:
patent: 3773921 (1973-11-01), Sheth et al.
patent: 4181708 (1980-01-01), Dannelly
patent: 4612186 (1986-09-01), Eckenhoff
patent: 4643893 (1987-02-01), Ascher
patent: 4789548 (1988-12-01), Tisdale
patent: 4865849 (1989-09-01), Conte
patent: 5082669 (1992-01-01), Shirai

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