Solid orally administerable raloxifene hydrochloride pharmaceuti

Details Solid orally administerable raloxifene hydrochloride pharmaceuti Solid orally administerable raloxifene hydrochloride pharmaceuti

1997-03-26

1998-09-22

Bawa, Raj

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424451, 424463, 424474, 424490, 514960, 514962, 514324, A61K 920, A61K 31445

Patent

active

058111204

ABSTRACT:
This invention provides solid orally administerable pharmaceutical formulations comprising raloxifene hydrochloride, a surfactant being sorbitan fatty acid ester or a polyoxyethylene sorbitan fatty acid ester, polyvinylpyrrolidone, and a water soluble diluent which is polyol or sugar.

REFERENCES:
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patent: 4418068 (1983-11-01), Jones
patent: 4797286 (1989-01-01), Thakkar et al.
patent: 4847092 (1989-07-01), Thakkar et al.
patent: 5112619 (1992-05-01), Thakkar et al.
patent: 5461064 (1995-10-01), Cullinan
patent: 5462950 (1995-10-01), Fontana
patent: 5510370 (1996-04-01), Hock
van Hoogdalem et al., Pharmac. Ther., 44, 407 (1989).
Dissolution, Bioavailability, and Bioequivalende, Mack Publishing Company, (1989), Chapter 5, Factors Affecting the Rate of Dissolution of Solid Dosage Forms.

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