Solid medicament formulations containing nifedipine, and process

Details Solid medicament formulations containing nifedipine, and process Solid medicament formulations containing nifedipine, and process

1992-06-01

1993-11-23

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546321, C07D21355, A61K 3144

Patent

active

052644464

ABSTRACT:
The invention is directed to the provision of solid pharmaceutical compositions (and methods for their preparation) containing nifidipine crystals with a specific surface area of 1.0 to 4.0 m.sup.2 /g., in admixture with a solid diluent. The said compositions overcome the deficiencies of prior art compositions containing nifidipine, which is known to have effect as a coronary vasodilator.

REFERENCES:
patent: 3330727 (1967-07-01), Lees
patent: 3485847 (1969-12-01), Bossert et al.
patent: 3784684 (1974-01-01), Bossert et al.
W. A. Ritschel, "In Vivo Animal Models for Bioavailablity Assessment", S. T. P. Pharama 3(2) 125-141, 1987.
Levy et al, "Development of In Vitro Dissolution Tests which . . . ", J. of Pharm. Sciences, vol. 54, No. 12 (1965) 1719-1722.
B. Katchen, "Correlation of Dissolution Rate and . . . ", J. of Pharm. Sciences, vol. 56, No. 9 (1967), 1108-1111.
"Benoxaprofen, A New Anti-Inflammatory Agent: Particle-Size Effect on Dissolution Rate and Oral Absorption in Humans", A. Ridolfo, L. Thompkins, L. D. Bechtol and R. H. Carmichael, Journal of Pharmaceutical Sciences, vol. 68, No. 7, Jul. 1979.
Von H. Schwela, et al, Medicamentum, Berlin, 19 258-261 (1978).
Sugimoto, Drug Development and Industrial Pharmacy, vol. 6, No. 2 (1980), pp. 137-151.
Patzschke et al, 2nd International "ADALAT" Symposium, edited by Wilhelm-Lochner-Wolfgang Braasch, pp. 27-32, (1975).
Journal of Phamaceutical Sciences, Nov. 1968, vol. 57, No. 11, "Particle Size of Drugs And Its Relationship To Absorption And Activity", Julian H. Fincher, pp. 1825-1835.
Drug Development and Industrial Pharmacy, vol. 6, No. 2, 1980, pp. 137-160.
Nature, Feb. 10, 1962, vol. 193, pp. 588-589, Atkinson et al, "Effect of Particle Size on Blood Griseofulvin-Levels in Man".

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