Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form
Patent
1994-04-12
1998-07-28
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
71DIG1, 252311, 252314, 2523635, 264 44, 424405, 424484, 424498, 42721332, 42840224, 514965, A61K 910, A61K 919, B01J 1300
Patent
active
057859760
ABSTRACT:
The present invention is in the area of administration forms and delivery systems for drugs, vaccines and other biologically active agents. More specifically the invention is related to the preparation of suspensions of colloidal solid lipid particles (SLPs) of predominantly anisometrical shape with the lipid matrix being in a stable polymorphic modification and of suspensions of micron and submicron particles of bioactive agents (PBAs); as well as to the use of such suspensions or the lyophilizates thereof as delivery systems primarily for the parenteral administration of preferably poorly water-soluble bioactive substances, particularly drugs, and to their use in cosmetic, food and agricultural products.
SLPs and PBAs are prepared by the following emulsification process:
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Pharmaceutical Research vol. 8 No. 2 1991, "Polymorphic Behavior of Sprayed Lipid Micropellets and its Evaluation by Differential Scanning Calorimetry and Scanning Electron Microscopy" pp. 178-184.
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Siekmann Britta
Westesen Kirsten
Lovering Richard D.
Pharmacia & UpJohn AB
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