Solid lipid compositions of lipophilic compounds for enhanced or

Details Solid lipid compositions of lipophilic compounds for enhanced or Solid lipid compositions of lipophilic compounds for enhanced or

1997-04-02

1999-11-23

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Food or edible as carrier for pharmaceutical

424456, 424464, 424465, 424452, 424450, 424489, 426590, 514169, 514724, 514728, 514962, A61K 914, A61K 920, A61K 948

Patent

active

059895837

ABSTRACT:
Lipophilic substances of poor oral bioavailability are mixed with at least one solid fat and phospholipid to obtain a dried solid composition suitable as an oral dosage form. The solid lipid compositions are exemplified for food additives or dietary supplements such as Coenzyme Q10 and for pharmaceuticals such as dexanabinol. The Coenzyme Q10-dry lipid mixtures shows improved drug release in vitro and enhanced oral bioavailability in vivo compared to a commercial CoQ10 formulation. The dexanabinol-dry lipid mixture similarly shows greatly enhanced oral bioavailability compared to known formulations.

REFERENCES:
patent: 4687782 (1987-08-01), Brantman
patent: 5179122 (1993-01-01), Greene et al.
patent: 5480865 (1996-01-01), Kingham
patent: 5665379 (1997-09-01), Herslof

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