Solid hydrochloride salt of t-PA

Details Solid hydrochloride salt of t-PA Solid hydrochloride salt of t-PA

1988-07-29

1990-11-06

Stone, Jacqueline

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435219, 435226, 424 9463, 424 9464, C12N 950, A61K 37547

Patent

active

049686178

ABSTRACT:
A lyophilised pharmaceutical formulation of tissue plasminogen activator and a process for its preparation by vacuum drying a frozen aqueous solution of thereof, in which the pH is from 2 to 5.

REFERENCES:
patent: 3998947 (1976-12-01), D'Hinterland et al.
patent: 4505893 (1985-03-01), Mori et al.
patent: 4568544 (1986-02-01), Hasegawa et al.
Collen et al., Biological Properties of Human Tissue-Type Plasminogen Activator Obtained by Expression of Recombinant DNA in Mammalian Cells, The Journal of Pharmacology and Experimental Therapeutics, pp. 146-152, vol. 231, 1984.
Hoylaerts et al., Kinetics of the Activation of Plasminogen by Human Tissue Plasminogen Activator, pp. 2912-2919, Journal of Biological Chemistry, vol. 257, No. 6, Mar. 25, 1982.
Zamarron et al., Kinetics of the Activation of Plasminogen by Natural and Recombinant Tissue-Type Plasminogen Activator, pp. 2080-2083, Journal of Biological Chemistry, vol. 259, No. 4, Feb. 25, 1984.
Rijken et al., Purification and Partial Characterization of Plasminogen Activator from Human Uterine Tissue, pp. 140-153, Biochimica et Biophysica Acts, (1979).
Hamaguchi, Mie Medical Journal, vol. XXXIII, No. 1, 1983, pp. 57 and 66 to 67, Partial Purification and Properties of Tissue-Type Plaminogen Activator from Nasal and Maxillary Mucosae.
Remington's Pharmaceutical Sciences, Fifteenth Ed. (1975), pp. 273-274.

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