Solid form of administration of isosorbide 5-mononitrate

Details Solid form of administration of isosorbide 5-mononitrate Solid form of administration of isosorbide 5-mononitrate

1997-01-24

1999-02-09

Krass, Frederick

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424463, 424465, 424470, 424474, 424493, 424497, 424498, 514964, 514965, A61K 950, A61K 3134

Patent

active

058690948

ABSTRACT:
A solid form of oral administration of isosorbide 5-mononitrate with a controlled, pH-independent release of the active substance in the gastro-intestinal tract is constituted by a pellet coated with a depot layer and a release prolonging lacquer layer. The lacquer layer contains ethyl cellulose and polymethacrylate in a weight ratio from 3:1 to 3:2. The new form of administration is characterized in that it is less costly to produce.

REFERENCES:
patent: 4812316 (1989-03-01), Rossi et al.
patent: 4828840 (1989-05-01), Sakamoto et al.
patent: 5149542 (1992-09-01), Valducci

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