Solid fat nanoemulsions as drug delivery vehicles

Details Solid fat nanoemulsions as drug delivery vehicles Solid fat nanoemulsions as drug delivery vehicles

1993-05-18

1996-11-19

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424489, 424490, 424502, 4284022, A61K 9127, A61K 916

Patent

active

055760163

ABSTRACT:
The present invention provides pharmaceutical compositions comprising nanoemulsions of particles comprising a lipid core which is in a solid or liquid crystalline phase at 25.degree. C, stabilized by at least one phospholipid envelope, for the parenteral, oral, intranasal, rectal, or topical delivery of both fat-soluble and water-soluble drugs. Particles have a mean diameter in the range of 10 to 250 nm. A wide variety of drugs and oxygen transporting perfluorocarbons may be encapsulated in the particles. In addition to drug delivery vehicles, the invention provides oxygen transporting blood substitutes, and nanoemulsions for extracorporeal maintenance of tissues prior to transplantation.

REFERENCES:
patent: 5023271 (1991-06-01), Vigne
patent: 5171737 (1992-12-01), Weiner
patent: 5188837 (1993-02-01), Domb
patent: 5284663 (1994-02-01), Speaker
patent: 5302401 (1994-04-01), Livensidge
patent: 5306508 (1994-04-01), Kossovsky
patent: 5308624 (1994-05-01), Maincent
CRC Press, Inc., Liposome Technology, 2nd Edition, vol. 1, Chapter 28, p. 501, Liposome Preparation and Related Techniques, edited by Gregory Gregoriadis, Ph.D., "A Large-Scale Method For The Preparation Of Sterile And Nonpyrogenic Liposomal Formulations Of Defined Size Distributions for Clinical Use", Shimon Amselem, Alberto Gabizon, and Yechezkel Barenholz.
Methods of Biochemical Analysis, vol. 33, D. Glick, editor, J. Wiley & Sons, N.Y., 1988, "Liposomes: Preparation, Characterization, and Preservation", Dov Lichtenberg and Yechezkel Barenholz.
Journal of Pharmaceutical Sciences, vol. 79, No. 12, Dec. 1990, "Optimization and Upscaling of Doxorubicin-Containing Liposomes for Clinical Use", S. Amselem, A. Gabizon and Y. Barenholz.
CRC Press, Inc., 1993, Liposome Technology, 2nd Ed., edited by G. Gregoriadis, Ph.D., vol. 1, Chapter 3, p. 49, "Liposome Peparation Using High-Pressure Homogenizers", Martin M. Brandl, Dieter Bachmann, Markus Drechsler, and Kurt H. Bauer.
Elsevier Science Publishers B.V. (Biomedical Division), 1986, Laboratory Techniques in Biochemistry and Molecular Biology, vol. 3, part 2, edited by R. H. Burdon and P. H. van Knippenberg, "Techniques of Lipidology--Isolation, Analysis and Identification of Lipids", 2nd revision edition, Moris Kates.

Affiliated with

Also associated with

Rating

Solid fat nanoemulsions as drug delivery vehicles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Solid fat nanoemulsions as drug delivery vehicles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Solid fat nanoemulsions as drug delivery vehicles will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-538948