Solid dose form of nanoparticulate naproxen

Details Solid dose form of nanoparticulate naproxen Solid dose form of nanoparticulate naproxen

1998-09-04

2000-12-26

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424 43, 424 44, 424464, 424465, 514569, A61K 946, A61K 914, A61L 904, A01N 3710

Patent

active

061655066

ABSTRACT:
Described are solid dose nanoparticulate naproxen formulations having high rates of dissolution. The solid dose nanoparticulate naproxen formulations can comprise an alkali compound, which functions to increase the dissolution rate of the naproxen following administration. Alternatively, the solid dose nanoparticulate naproxen formulation can comprise an alkali compound and an acidic compound, which can react together to form carbon dioxide. The formed carbon dioxide can also aid in increasing the dissolution rate of the naproxen following administration. Also described are solid dose nanoparticulate naproxen formulations having a decreased concentration of a binder/disintegrant agent. Such compositions also provide an increased rate of dissolution of naproxen following administration.

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