Solid Coprecipitates for enhanced bioavailability of lipophilic

Details Solid Coprecipitates for enhanced bioavailability of lipophilic Solid Coprecipitates for enhanced bioavailability of lipophilic

1997-04-02

1999-04-06

Harrison, Robert H.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424439, 424452, 424464, 424465, 424489, 424502, 514458, 514960, A61K 948, A61K 920

Patent

active

058914692

ABSTRACT:
Lipophilic active ingredients are co-melted with tocopherol polyethyleneglycol succinate (TPGS) and a dispersion adjuvant to obtain solid dry coprecipitate compositions suitable as an oral dosage form. The solid TPGS coprecipitates of lipophilic active ingredients show improved drug release in vitro and enhanced oral bioavailability in vivo.

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