Drug – bio-affecting and body treating compositions – Dentifrices – Hydroxy carboxylic acid or derivative thereof
Reexamination Certificate
2000-02-17
2002-05-07
Fay, Zohreh (Department: 1614)
Drug, bio-affecting and body treating compositions
Dentifrices
Hydroxy carboxylic acid or derivative thereof
C426S074000, C426S590000, C426S648000, C426S650000, C426S649000
Reexamination Certificate
active
06383473
ABSTRACT:
The present invention relates to compositions for oral use, in particular solid or semi-solid acidic products and oral healthcare compositions, and to the use of calcium in such compositions to alleviate or prevent the tooth damage associated with the consumption of acid. In particular, the present invention alleviates palatability problems associated with calcium addition to products.
It is thought that erosion of teeth is caused inter alia by acidic foodstuffs leaching out calcium from the teeth faster than it can be replaced by normal remineralisation processes. When a product is prepared in accordance with this invention, and introduced into the oral cavity for consumption or healthcare purposes, the dissolution or removal of calcium and phosphate from teeth by chemical processes is significantly reduced.
Calcium is the most abundant mineral in the body. The vast majority of calcium is deposited in the bones and teeth but the mineral is also essential for other bodily functions such as the regulation of nerve function. the contraction of muscles and clotting of blood. Calcium is a common constituent of beverages being derived from fruit ingredients and from hard water when this is used in beverage production without prior softening. Values for the concentration of calcium occurring in this way are typically in the range 0.005-0.02% w/w. Interest in the general nutritional benefits of diet fortification by calcium ion has led to a search for practical ways to incorporate this ion at higher levels from 0.02% w/w to 2% w/w. The use of calcium as a supplement for beverages has been described in W088/03762.
It is well known that the addition of malic acid will help maintain the solubility of calcium in calcium fortified beverages therefore minimizing losses due to precipitation. This is because of the formation of a soluble complex “calcium citrate malate”. On the other hand, Lussi et al (1995, Caries Res 29, 349-354) have associated the titratable acidity of a beverage with its erosive potential; the greater the concentration of acid in the beverage the more damaging to teeth it became.
In EP 551398 (Procter & Gamble) there is disclosed a method for preventing the erosion of tooth enamel by consuming an acid beverage (having a pH of lees than 5.5) comprising from 0.02% to 0.15% of calcium in the form of a calcium citrate malate complex having a molar ratio of citrate to malate of 1:0.5 to 1:4.5. In the calcium citrate malate complexes the molar ratio of total moles calcium:total moles citrate:total moles malate may be from about 2:1:1 to about 6:3:4. A preferred complex for beverages has the molar ratio 4:2:3. U.S. Pat. No. 5,073,389 describes the use of calcium citrate malate to provide a mineral supplemented candy product.
We have found that inclusion of high levels of calcium in products gives palatability problems. However, we have found that effective reduction of tooth erosion in acidic oral compositions can be achieved without impairing palatability using lower amounts of calcium relative to the acidulant when the pH of the composition is also controlled. WO 97/30601 (published Aug. 28, 1997) discloses controlled pH liquid compositions containing calcium and an acidulant in a defined ratio.
The present invention provides a solid or semi solid composition for oral use containing a calcium compound and an acidulant characterised in that calcium is present in the range of 0.3 to 0.8 mol per mol of acid and that the amount of calcium and acidulant in the composition is selected so that the effective pH of the composition is from 3.5 to 4.5.
The term effective pH is used in the context of the present invention to mean the pH of the composition before solidification (where the composition is prepared via a liquid phase intermediate) or the pH of the composition when reconstituted or dissolved in a liquid, eg. water. The term solidification encompasses the treatment or supplementation of liquid phase intermediates to form a solid or semi-solid.
In another aspect, the present invention provides the use of calcium as a tooth erosion inhibitor in a solid or semi-solid acidic composition for oral administration comprising a calcium compound and an acidulant, characterised in that calcium is present in the range of 0.3 to 0.8 mol per mol of acid and that the amount of calcium and acidulant in the composition is selected so that the effective pH of the composition is from 3.5 to 4.5.
In a further aspect, the present invention provides a method of reducing the tooth erosion potential of a solid or semi-solid acidic oral composition comprising adding calcium to the acidic oral composition so that calcium is present in the range of 0.3 to 0.8 mol per mol of acid and the effective pH is from 3.5 to 4.5, obtaining an effective pH within the range 3.5 to 4.5 by addition of an alkali, if necessary or desired.
The invention also extends to a method of reducing tooth erosion caused by acid in orally administered compositions comprising orally administering a solid or semi-solid composition comprising a calcium compound and an acidulant, characterised in that calcium is present in the range of 0.3 to 0.8 mol per mol of acid and that the amount of calcium and acidulant in the composition is selected so that the effective pH of the composition is from 3.5 to 4.5.
The invention further extends to the use of a solid or semi-solid composition comprising a calcium compound and an acidulant in the manufacture of a medicament for the reduction of tooth erosion caused by acid in orally administered compositions, characterised in that calcium is present in the range of 0.3 to 0.8 mol per mol of acid and that the amount of calcium and acidulant in the composition is selected so that the effective pH of the composition is from 3.5 to 4.5.
In a still further aspect, the present invention provides a process for preparing a composition of this invention which comprises mixing a calcium compound with an acidulant so that calcium is present in the range of 0.3 to 0.8 mol per mol of acid and the effective pH of the composition is from 3.5 to 4.5. If necessary or desired an effective pH within the range 3.5 to 4.5 can be obtained by addition of an alkali.
The present invention is particularly applicable to solid or semi solid acidic substances for oral consumption such as boiled sweets, candies, tablets, lozenges, lollies, chews, jellies, gums, drops, dry powder blends such as powdered drinks intended for dissolution, eg. in water, and the like. Semi solid products also include dairy products such as yoghurts and set or frozen drinks.
Suitably the composition before solidification is prepared and tested using the techniques described in WO 97/30601, the entire contents of which are herein incorporated by reference.
The effective pH for compositions of the invention is higher than normally associated with acid-based products for human consumption which typically have an effective pH of about pH 3 in order to maintain palatability associated with sharpness in taste. Practice of the present invention does not cause taste defects in products. Although an increase in effective pH to around pH 4 would be expected to reduce the sharpness in taste provided by the acidulant, surprisingly the inclusion of calcium in accordance with this invention mitigates this.
A further advantage arises from the use of low levels of calcium in accordance with this invention, suitably in the form of an alkaline salt. The buffering capacity of the formulation is reduced by partial neutalisation of the acid, which allows saliva to neutralise remaining acid residues in the mouth more rapidly.
The absolute concentration of calcium used in the compositions of the present invention is not critical as this will vary according to the nature and concentration of the acids present. The acid composition may contain organic and/or inorganic acids and may be supplemented with vitamins such as ascorbic acid. The calcium concentration may vary from 0.001 mol. per liter to more than 0.25 mol. per liter, typically from 0.002 mol. per liter to 0.1 mol.
Dinner Dara L.
Fay Zohreh
Kinzig Charles M.
Kwon Brian-Yong
SmithKline Beecham p.l.c.
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