Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1992-10-07
1995-02-14
Kishore, G. S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424490, 424498, 424600, 424617, 424630, 424635, 424639, 424641, 424644, 424646, 424650, 42840224, A61K 9127
Patent
active
053893778
ABSTRACT:
A liposome composition which comprises a substantially uniform sized inorganic core coated with an amphipathic organic compound and further coated with a second amphipathic vesicle forming lipid. Also disclosed are novel phenyl lipid compounds which serve as the amphipathic vesicle forming lipid and methods are described for delivering a drug for slow release into the blood stream, and for targeting a selected tissue or cells with the inorganic core liposome compositions.
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Chan et al, "Magnetic Resonance Imaging of Abscesses Using Lipid-Coated Iron Oxide Parties", pp. 443-449, Jun. 1992.
Dinger et al, "Safety Profile of Gd-DTPA: Clinical Experience", Berlin, West Germany, Abstract only, Nov. 1990.
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Reimer et al, "Improved Detection of Liver Cancer with Hepatocyte-directed superparamagnetic Iron Oxide Particles" Charlestown, Mass., Abstract only, Nov. 1990.
Chan, et al, "MR Imaging of Abscess by Use of Lipid-coated Iron Oxide Particles", Philadelphia, Pa., Abstract only, Nov. 1990.
Carter Michelle J.
Chagnon Mark S.
Ferris John R.
Hamilton Tracy J.
Rudd Edwin A.
Kishore G. S.
Molecular Bioquest, Inc.
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