Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-01-25
2005-01-25
Wilson, James O. (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S116000, C536S119000, C536S120000, C536S055100, C536S123100, C536S123120, C536S124000, C536S126000
Reexamination Certificate
active
06846917
ABSTRACT:
Described is a modular, general synthetic strategy for the preparation in solution and on a solid support of heparin, heparin-like glycosaminoglycans, glycosaminoglycans and non-natural analogs of each of them. Additionally, the modular strategy provides the basis for the preparation of combinatorial libraries and parallel libraries of defined glycosaminoglycan oligosaccharides. The defined glycosaminoglycan structures may be used in high-throughput screening experiments to identify carbohydrate sequences that regulate a host of recognition and signal-transduction processes. The determination of specific sequences involved in receptor binding holds great promise for the development of molecular tools which will allow modulation of processes underlying viral entry, angiogenesis, kidney diseases and diseases of the central nervous system. Notably, the present invention enables the automated synthesis of glycosaminoglycans in much the same fashion that peptides and oligonucleotides are currently assembled.
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International Search Report Completed on Jun. 5, 2002 and Mailed on Aug. 20, 2002.
Orgueira Hernan
Schell Peter
Seeberger Peter H.
Foley & Hoag LLP
Gordon Dana M.
Krishnan Ganapathy
Massachusetts Institute of Technology
Wilson James O.
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