Solid amino acid products for polypeptide synthesis and method o

Details Solid amino acid products for polypeptide synthesis and method o Solid amino acid products for polypeptide synthesis and method o

1973-06-04

1976-04-06

Foelak, Morton

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

260 25N, 2601125R, 424 78, 424177, 424178, C08J 916

Patent

active

039488217

ABSTRACT:
Macroreticular polystyrene resin having a surface area of at least 5 and preferably at least 50 square meters/gram and a majority of pores of at least 30 Angstroms diameter is utilized as a solid base support for polypeptide synthesis; linkage of the first amino acid of the peptide to said base being effected through chloromethylation of the base, blocking of the amine function of the acid and esterifying the amino acid with the chloride; the esterification being conducted in the presence of an inert high dielectric constant solvent most preferably acetonitrile. Preferably, the macroreticular solid base support is an aromatic hydrocarbon resin or polymer unsubstituted with nitro or bromo groups, such as the unsubstituted macroreticular polystyrene, above described.

REFERENCES:
patent: 3173892 (1965-03-01), Kun
Merrifield, R. B., "Solid Phase Peptide Synthesis", J.A.C.S., Vol. 85 (1963), pp. 2149-2154.
Merrifield, R. B., "Solid Phase Peptide Synthesis", Endeavour Vol. 24 (1965), pp. 3-7.

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