Liquid purification or separation – With means to add treating material – Chromatography
Reexamination Certificate
2006-02-14
2006-02-14
Therkorn, Ernest G. (Department: 1723)
Liquid purification or separation
With means to add treating material
Chromatography
C210S502100, C210S635000, C210S656000, C204S600000
Reexamination Certificate
active
06998040
ABSTRACT:
The present invention provides for a column for use in capillary electrochromatography including a tube, wherein the tube includes an inner surface having a positively or negatively charged, chemically-bonded stationary coating thereon. The present invention further provides for a method of making a column for use in capillary electrochromatography, including a tube, wherein the tube includes an inner surface having a positively or negatively charged chemically-bonded stationary coating thereon, wherein the steps include filling the column with a sol-gel solution, maintaining the sol-gel solution within the column, and forcing the sol-gel solution out of the column with an inert gas. Further, the present invention provides for a method of analytical separation with a column including an inner layer having a positively charged chemically-bonded stationary coating thereon that reverses the direction of electroosmotic flow in the column compared with a column without the positive surface charge. Additionally, the present invention provides for a method of using a column including an inner layer of positively charged chemically-bonded stationary coating thereon by introducing a sample into the column operating under reversed electroosmotic flow due to positively charged chemically-bonded stationary coating.
REFERENCES:
patent: 4123931 (1978-11-01), Blaser
patent: 5145579 (1992-09-01), Eguchi et al.
patent: 5431807 (1995-07-01), Frechet et al.
patent: 5624875 (1997-04-01), Nakanishi et al.
patent: 6136187 (2000-10-01), Zare et al.
patent: 6210570 (2001-04-01), Holloway
patent: 6562744 (2003-05-01), Nakanishi et al.
patent: 2003/0213732 (2003-11-01), Malik et al.
Snyder, (Introduction to Modern Liquid Chromatography, John Wiley & Sons, New York (1979), pp. 278-280.
Bigham, S., et al., “Sol-Gel Capillary Microextraction,” Anal. Chem. vol. 74, No. 4, pp. 752-761, 2002.
Bruin, G. et al., “Electrically driven open-tubular liquid chromatography,” Journal of Chromatography, 517, pp. 557-572, 1990.
Chong, S. et al., “Sol-Gel Coating Technology for the Preparation of Solid-Phase Microextraction Fibers of Enhanced Thermal Stability,” Anal. Chem., 69, pp. 3339-3898, 1997.
Dittmann, M. et al., “Capillary Electrochromatography: Investigation of the Influence of Mobile Phase and Stationary Phase Properties on Electroosmotic Velocity, Retention, and Selectivity,” J. Microcolumn., 9, pp. 399-408, John Wiley & Sons, Inc. 1997.
Folestad, S. et al., “Performance and preparation of immobilized polysiloxane stationary phases in 5-55 μm I.D. open-tubular fused silica columns for liquid chromatography,” Abstract, Journal of Chromatography, vol. 391, pp. 347-372, 1987. (Abstract only).
Gamer, T.W. et al., “Increased selectivity for electrochromatography by dynamic ion exchange,” Abstract, Journal of Chromatography, vol. 640, pp. 397-402, 1993. (Abstract only).
Göhlin, K. et al., “Study of polyorganosiloxanes (native and solvent swollen) for the preparation of narrow (5-15 μm I.D.) and long (1-6m) open tubular columns in reversed-phase liquid chromatography,” Abstract, Journal of Chromatography, vol. 645, pp. 41-56, 1993. (Abstract only).
Göhlin, K. et al., “Narrow (5-50 μm I.D.) Open Tubular Columns in Liquid Chromatography Using Immobilizing Polymethyl-octadecylsiloxane as Stationary Phase,” Journal of Microcolumn, Sep. 3, pp. 547-556, 1991.
Guo, Y., et al., “A Stationary Phase for Open Tubular Liquid Chromatography and Electrochromatography Using Sol-Gel Technology,” Anal. Chem., 67, pp. 2511-2516, 1995.
Hayes, J. et al., “Sol-gel chemistry-based Ucon-coated columns for capillary electrophoresis,” Journal of Chromatography, vol. 695, pp. 3-13, 1997.
Hayes, J.D. et al., “Sol-Gel Monolithic Columns with Reversed Electroosmotic Flow for Capillary Electrochromatography,” Anal. Chem., 72, pp. 4090-4099, 2000.
Hibi, K. et al., “Studies of open-tubular microcapillary liquid chromatography, III. β, β'- oxydipropionitrile and ethylene glycol stationary phases,” Abstract, Journal of Chromatography, vol. 175, pp. 105-111, 1979. Abstract Only.
Ishli, D. et al., “Studies of open-tubular microcapillary liquid chromatography, IV. Soda-lime glass columns treated with alkaline solution,” Abstract, Journal of Chromatography, vol. 185, pp. 73-78, 1979. Abstract Only.
Jorgenson, J. et al., “New techniques for liquid chromatography in open-tubular columns,” Abstract, Journal of Pharmaceutical and Biomedical Analysis, vol. 2, pp. 191-196, 1984. Abstract Only.
Jorgenson, J.W. et al., “Liquid chromatography in open-tubular columns—Theory of column optimization with limited pressure and analysis time, and fabrication of chemically bonded reversed-phase columns on etched borosilicate glass capillaries,” Abstract, Journal of Chromatography, vol. 255, pp. 335-348, 1983. Abstract Only.
Malik, A. et al., “Sol-Gel Technology for Thermally Stable Coatings in SPME,” In Applications of Solid-Phase Microextraction; Royal Society of Chemistry; London, U.K., Chapter 6, pp 73-91, 1999.
Pesek, J. et al., “Electrochromatography in chemically modified etched fused-silica capillaries,” Journal of Chromatography, 736, pp. 255-264, 1996.
Pesek, J. et al., “Separation of tetracyclines by high-performance capillary electrophoresis and capillary electrochromatography,” Journal of Chromatography, 736, pp. 313-320, 1996.
Pfeffer, W.D. et al., “Electroosmotically driven electrochromatography of anions having similar electrophoretic mobilites by ion pairing,” Abstract, Journal of Chromatography, vol. 557, pp. 125-136, 1991. Abstract Only.
Sawada, H. et al., “Preparation of capillary columns coated with linear polymer containing hydrophobic and charged groups for capillary electrochromatography,” Electrophoresis., 20, pp. 24-30, 1999.
Swart, R. et al., “Preparation and evaluation of polyacrylate-coated fused-silica capillaries for reversed-phase open-tubular liquid chromatography,” Abstract, Journal of Chromatography, vol. 670, pp. 25-38, 1994. Abstract Only.
Tan, Z. et al., “Preparation and Evaluation of Bonded Linear Polymethacrylate Stationary Phases for Open Tubular Capillary Electrokinetic Chromatography,” Anal. Chem., 69, pp. 581-586, 1993.
Tsuda, T. et al., “Open-Tubular Microcapillary Liquid Chromatography with Electro-Osmosis Flow Using A UV Detector,” Journal of Chromatography, vol. 248, pp. 241-247, 1982.
Van Berkel, et al., “The Application of Immobilized Liquids for Open-Tubular Liquid Chromatography,” Chromatographia, vol. 24, pp. 739-744, 1987.
Wang, D., et al., “Sol-Gel Column Technology for Single-Step Deactivation, Coating, and Stationary-Phase Immobilization in High-Resolution Capillary Gas Chromatography,” Anal Chem., 69, pp. 4566-4576, 1997.
Zhang, Y. et al., “High Performance Micellar Liquid Chromatography with Silica Micro-Particles Having Surface-Bound Cationic Surfactant Moieties. I. Comparison with Octadecylsilica and Applications to the Separation of Dansyl Amino Acids, Herbicides, and Catecholamines,” Journal of Liquid Chromatography, 18, pp. 3373-3396, 1995.
Van Berkel-Geldof, O. et al., “Preparation of silicone-coated 5-25-μm I.D. fused-silica capillary columns for open-tabular liquid chromatography,”Journal of Chromatography A, vol. 449, 345-359 (1990). Abstract Only.
Yang, Changming, et al., “Capillary zone electrophoresis of proteins with fused-silica capillaries having polymers and surfactants adsorbed onto surfactant moieties previously covalently bound to the capillary column surface,”Electrophoresis, 19, 2278-2284 (1998).
Tsuda, Takao, et al., “Open-tubular microcapillary liquid chromatography with 20-μm I.D. colums,”Journal of Chromatography A., vol.
Hayes James D.
Malik Abdul
Saliwanchik Lloyd & Saliwanchik
Therkorn Ernest G.
University of South Florida
LandOfFree
Sol-gel open tubular ODS columns with charged inner surface... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sol-gel open tubular ODS columns with charged inner surface..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sol-gel open tubular ODS columns with charged inner surface... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3660440