Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1991-09-11
1993-04-06
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424441, 424456, 264 43, 264 44, A61K 948
Patent
active
052001911
ABSTRACT:
After softgels are encapsulated and dried in a drying tunnel, the resulting softgels are subjected to a further stress relieving step. During the stress relieving step, the temperature and humidity conditions in the drying tunnel are heightened. By utilizing the stress relieving step, the volume and number of dimples and bubbles in the softgels are reduced, and dimensional uniformity is maximized.
REFERENCES:
patent: 4067960 (1978-01-01), Fadda
patent: 4166800 (1979-09-01), Fong
patent: 4198391 (1980-04-01), Grainger
patent: 4744988 (1988-05-01), Brox
patent: 4780316 (1988-10-01), Brox
patent: 4816259 (1989-03-01), Matthews
patent: 4892766 (1990-01-01), Jones
patent: 4935243 (1990-06-01), Borkan
patent: 5023024 (1991-06-01), Kyogoku
P. Johns & A. Courts, The Science and Technology of Gelatin, "Relationship between Collagen and Gelatin", 1977.
Canadian Journal of Pharmaceutical Sciences, "The Mechanical Properties of Gelatin Films", vol. 13, No. 4 (1978).
Nature, "The Incipient Shrinkage of Collagen and Gelatin", vol. 159, p. 538 (Apr. 19, 1947).
Journal of Applied Polymer Science, "Creep Studies on Gelatin at 100% Relative Humidity", vol. IV, Issue No. 11, pp. 200-202 (1960).
P. Tyle, editor, Specialized Drug Delivery Systems, "Softgels: Manufacturing Considerations", Marcel Dekker, Inc., pp. 409-449 (1990).
Van Hostetler & J. Q. Bellard, The Theory and Practice of Industrial Pharmacy, "Capsules", pp. 346-383 (1970).
M. S. Patel, F. S. Morton and H. Seager, Manufacturing Chemists, "Advances in Softgel Formulation Technology", (Jul. 1989).
William R. Ebert, Pharmaceutical Technology, "Soft Elastic Gelatin Capsules: A Unique Dosage Form", Oct. 1977.
H. Seager, Pharmaceutical Technology, "Soft Gelatin Capsules: a solution to many tableting problems", Sep. 1985.
A. Veis, The Macromolecular Chemistry of Gelatin, "Physical Properties of Collagen Fibers", 1964.
Dietel Gregory
Steele Don
Banner Gelatin Products Corp.
Benston, Jr. William E.
Page Thurman K.
LandOfFree
Softgel manufacturing process does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Softgel manufacturing process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Softgel manufacturing process will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-534773