Soft tissue implant with micron-scale surface texture to optimiz

Details Soft tissue implant with micron-scale surface texture to optimiz Soft tissue implant with micron-scale surface texture to optimiz

1990-04-20

1991-04-30

Cannon, Alan W.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

623 1, 623 2, 623 8, 600 36, A61F 202, A61F 206, A61F 212, A61F 224

Patent

active

050114948

ABSTRACT:
A soft tissue implant device such as a catheter, heart valve, or plastic or reconstructive surgical material, to be at least partially embedded in an implantation site in soft organic tissue of a living organism includes a body defining a surface layer extending over the portion of the body contacting the organic tissue. The surface layer defines a three-dimensional pattern with an exterior surface defining a plurality of spaces and a plurality of solid surface portions. The spaces have a mean bridging distance ranging from greater than 1.0 micron to less than 4.0 microns and the solid surfaces portions have mean breadths ranging from 0.10 micron to 2.0 microns. The mean bridging distance is preferably greater than 1.4 microns and less than 1.9 microns. The exterior surface is substantially free of indentations having a bridging distance measuring in a range from between 10.0 microns and 1,000 microns.

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Boyce, Biologic and Synthetic Vascular Prostheses, "Physical Characteristics of Expanded Polytetrafluoroethylene Grafts", pp. 553-561 (1982), FIGS. 33-2 and 33-3.
Campbell et al., Surgery, "Expanded Microporous Polytetrafluoroethylene as a Vascular Substitute: A Two Year Follow-up," vol. 85, pp. 177-183 (1979), FIG. 1A.
Campbell et al., Annals of Surgery, "A Small Arterial Substitute, Expanded Microporous Polytetrafluoroethylene: Patency Versus Porosity", vol. 182, pp. 138-143 (1975), FIG. 1.
Kester, Biomat., Med. Dev., Art. Org., "Reinforced Expanded Polytetrafluoroethylene (Gore-Tex) Grafts for Haemodialysis", vol. 6, No. 4, pp. 331-340 (1978), FIG. 2.
Squier et al., "The Relationship Between Soft Tissue Attachment, Epithelial Downgrowth, and Surface Porosity", Journal Periodontal Research, vol. 16, pp. 434-440, 1981.
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Eskin et al., "Endothelial Cell Culture on Dacron Fabrics of Different Configurations", J. Biomed. Mat. Res., vol. 12, pp. 517-524 (1978).

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