Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1980-10-31
1983-04-26
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
2602395, 2602391, 26039745, 2603971, 560121, 560146, 424238, 424239, 424313, 424243, A61K 3143, A61K 3156, C07J 700
Patent
active
043813070
ABSTRACT:
Novel derivatives of known bio-affecting carboxylic acids R-COOH are disclosed, said derivatives having the structural formula ##STR1## wherein Y and Y' are each H or C.sub.1 -C.sub.4 alkyl; n is 0 or 1; R.sub.1 and R.sub.2 are each selected from a variety of unsubstituted or substituted hydrocarbon radicals, or are combined so that --NR.sub.1 R.sub.2 represents the residue of a saturated or unsaturated heterocyclic compound containing one secondary nitrogen atom; and R.sub.3 is H or one of a variety of other substituents. Salts and N-oxides of compounds of formula (I) and the corresponding diacyloxy derivatives of known bio-affecting carboxylic acids HOOC-R'-COOH are disclosed also. The parent acids from which the subject soft tertiary amine esters can be derived include such bio-affecting agents as cephalosporin and penicillin antibiotics, amino acids and structurally related compounds, prostaglandins and their metabolites, steroidal anti-inflammatory agents, and non-steroidal anti-inflammatory
on-narcotic analgesic/antipyretic agents.
REFERENCES:
patent: 4218451 (1980-08-01), Feyen et al.
patent: 4241062 (1980-12-01), Hannah
patent: 4260625 (1981-04-01), Hardy et al.
Cheng Theresa Y.
Merck & Co. , Inc.
Monaco Mario A.
Roberts Elbert L.
Sudol, Jr. Michael C.
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