Soft steroids having anti-inflammatory activity

Details Soft steroids having anti-inflammatory activity Soft steroids having anti-inflammatory activity

1985-04-08

1987-12-01

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

540 36, 540 38, 26039745, 514179, 514180, A61K 3158, A61K 3156, C07J 2100, C07J 100

Patent

active

047104953

ABSTRACT:
Novel soft steroid anti-inflammatory agents, said agents being esters or thioesters of 17.alpha.-alkoxy-11.beta.-hydroxyandrost-4-en-3-one-17.beta.-carboxylic acids, pharmaceutical compositions containing said agents, novel chemical intermediates useful in the preparation of said agents and methods of administering same to mammals in the treatment of inflammation. Preferred compounds are the haloalkyl esters of 17.alpha.-alkoxy-11.beta.-hydroxyandrost-4-en-3-one-17.beta.-carboxylic acids.

REFERENCES:
patent: 3558675 (1971-01-01), Sarett et al.
patent: 3856828 (1974-12-01), Phillipps et al.
patent: 4093721 (1978-06-01), Phillipps et al.
patent: 4263289 (1981-04-01), Edwards

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