Soft quaternary surface active agents and method of using same

Details Soft quaternary surface active agents and method of using same Soft quaternary surface active agents and method of using same

1978-12-13

1980-05-20

Hollran, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548134, 548214, 548247, 548341, 260239E, 2603261, 26032613D, 424244, 424250, 424251, 424258, 424263, 424266, 424770, 424774, 544 39, 544224, 544237, 544283, 544335, 544336, 544347, 544353, 546146, 546174, 546318, 546334, 546341, 546342, 548378, A61K 31465

Patent

active

042040655

ABSTRACT:
Soft quaternary surface active agents having the formula: ##STR1## wherein >N represents a tertiary open chain or cyclic aliphatic amine; wherein >N represents an unsaturated amine; wherein R represents a member selected from the group consisting of a hydrogen atom, a C.sub.1 -C.sub.20 open chain or cyclo alkyl group, a C.sub.1 -C.sub.20 alkoxyalkyl group, a C.sub.1 -C.sub.20 acyloxyalkyl group, a C.sub.1 -C.sub.20 haloalkyl group, a C.sub.1 -C.sub.20 carboxyalkyl group, an aryl group, and a substituted aryl group, whose substituents are selected from the group consisting of a halogen atom, an O--C.sub.1 -C.sub.4 alkyl group, an O--C.sub.1 -C.sub.8 acyl group, a nitro group, a carboxyl group, and a carboethoxy group; wherein R.sub.1 represents a C.sub.9 -C.sub.22 straight or branched alkyl group, a --(CH.sub.2).sub.n -- ##STR2## group, wherein R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are each selected from the group consisting of a hydrogen atom, a methyl group or an ethyl group, a C.sub.0 -C.sub.22 straight or branched alkyl-(CH.sub.2).sub.n ##STR3## (CH.sub.2).sub.m CH.sub.3 group, wherein n in each occurrence and m represents an integer of from 0 to 22, an A-CH.sub.2 ##STR4## CH.sub.2 -A-CH.sub.3 group, wherein A represents a C.sub.0 -C.sub.22 straight or branched alkyl group as above or a --(CH.sub.2 CH.sub.2 O) group, wherein the p represents an integer of from 0 to 22, and the residue of any naturally occurring bile acid or synthetic derivative thereof; and wherein X represents a halogen atom or any other organic or inorganic monovalent anion are disclosed.
All compounds encompassed within the above-described generic formulae find use as "soft" antibacterial agents of extremely low toxicity.

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