Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Reexamination Certificate
2000-11-07
2003-01-14
Page, Thurman K. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
C424S455000, C424S463000, C424S489000, C424S500000, C424S725000, C424S776000, C514S925000
Reexamination Certificate
active
06506406
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a soft capsule containing mastic oil therein, and more particularly, the present invention relates to a soft capsule in which oil produced by dissolving mastic into oils and fats is contained.
2. Description of the Related Art
Mastic is a kind of resin in transparent and colorless, or somewhat in light-yellow color. Mastic is originally in a form of pine-tree gum produced from an anacardiaceous plant which is native in Khios Island, Greece, and is used as the material for chewing gums, that is, as the natural base for producing the gum. Recently, it has been reported several times that mastic has effects of removal and inhibitory action against helicobacter pyloric bacteria. Consequently, mastic attracts a great deal of attention as one of the material for health food.
The helicobacter pyloric bacterium is a Gram-negative bacterium which has been supposed to cause several kinds of digestive organ disease such as the chronic gastris, gastric ulcer, duodenal ulcer, stomach cancer, etc., and it has been said that the helicobacter pyloric bacteria live in the stomach of more than 80% of Japanese people who are 50 years old or more. Thus the removal and inhibition of multiplication of the helicobacter pyloric bacteria are believed to be one of the most practical and effective measures to prevent the occurrence of digestive organ disease.
However, since the helicobacter pyloric bacteria live deep in the epithelia of the mucous membrane cells which are positioned at the lowest part of the mucous strain (the mucous strain protects the inner wall of the stomach against the gastric juices), and since the helicobacter pyloric bacteria themselves have the defense effect against the stomach acids, the removal and inhibition thereof are quite difficult even by any pharmaceutical such as an antibiotic or an antibacterial agent. In addition, since there may often be the case that the medication of pharmaceuticals for a long period or the increase of amount of pharmaceuticals should be required;, there arises an anxiety of the side effect by these pharmaceuticals.
Therefore, since there has been awaited to be provided with the medicine which has no side effect and at. the same time has the considerable effects for removal and inhibition of the helicobacter pyloric bacteria, and since mastic may serve as a food material, the discovery of the removal and inhibitory effects of mastic as to the helicobacter pyloric bacteria is the good news for those who suffer from the digestive organ disease.
However, as mastic has the anti-soluble characteristic and the strong and unacceptable taste, the production of health food by using mastic would require several limitations. Thus, although there have been several kinds of health food using mastic, such as that in a form of chewing gum with the exceedingly sweet taste, or that containing mastic in a hard capsule after coarsely crushing mastic to be the granulated powder, they would be the limit of variation of health food containing mastic.
With regard to the health food according to the prior art as above discussed, in which mastic is used, it is insufficient to remove and inhibit the helicobacter pyloric bacteria, as will be discussed later in the experimental data of the present invention. The main reason is that, according to the prior art, since mastic has been used in an original solid form, even if the solid mastic is ingested, mastic will not sufficiently infiltrate into the epithelia of the mucous membrane cells. Consequently, the effect of mastic against the helicobacter pyloric bacteria will tend to be indirect and for the short time.
SUMMARY OF THE INVENTION
In the light of problems which have been described as above, the object of the present invention is to provide a composition containing mastic, with no side effect to human being, and with considerable effect to remove and inhibit the helicobacter pyloric bacteria.
For the object as above discussed, the inventor devoted himself to the research of composition by using mastic which has the good effect to remove and inhibit the helicobacter pyloric bacteria, and completed the present invention. According to the present invention, mastic is first dissolved in oils and fats such as a vegetable oil, animal oil, mineral oil, etc., in order to obtain mastic oil. Then, the mastic oil is filled in a soft capsule, or the mastic oil to which an amphipathic substance is added is filled in the soft capsule, or the mastic oil to which chitin or chitosan is added is filled in the soft capsule. The thus produced soft capsule has been proven to have the considerable effect to remove and inhibit the helicobacter pyloric bacteria.
According to claim
1
of the present invention, there is provided a soft capsule containing as contents oil which is produced by dissolving mastic in oils and fats.
According to claims
2
and
3
, the soft capsule further comprises amphipathic substance added to the oils and fats. The amphipathic substance may be surfactant, ethanol or ethanol solution.
According to claims
4
,
5
and
6
, the soft capsule further comprises chitin or chitosan added to the oils and fats.
According to claims
7
through
12
, the soft capsule serves the reduction effect of smell of feces.
DETAILED DESCRIPTION OF THE INVENTION
An embodiment of the present invention will now be, described in detail.
Oils and fats used in the present invention would mean oily substances contained in vegetable, animal, mineral, etc., and would also mean their products, such as the oils and fats themselves, or compound lipid such as phospholipid, or was, fatty acid, tryglyceride, etc.
The oily substances contained in vegetables, and their products, would mean vegetable oils and their products, such as the oils and fats, wax, phospholipid, etc., contained in the leaf, the seed or the fruit of vegetable. These would cover, for example, safflower oil, corn oil, olive oil, rape seed oil, rice oil, soybean oil, soybean lecithin, carnauba wax, candelilla wax, linoleic acid, linolenic acid, oleic acid, middle-chain fatty acid, coconut hardened oil, rape seed hardened oil, tocopherol, Beta-carotene, retinol, etc.
The oily substances contained in animals, and their products, would mean animal oils and their products, such as the oils and fats, was, phospholipid, etc., contained in the subcutaneous tissue, the abdominal cavity, the liver, the secretion of animal. These would cover, for example, fish oil such as sardine oil, tuna oil, cod-liver oil, squalene, and whale oil, beef lard, pork lard, egg yolk lecithin, arachidonic acid, bees wax, lanolin, beef hardened oil, pork hardened oil,etc. The mineral oil would cover paraffin, fluid paraffin, etc.
The oils and fats of which polarity are higher may have better solubility of mastic, thus may be a good solvent. Therefore, as compared with the oils and fats containing much amount of long-chain fatty acid, those containing much amount of middle- or short-chain fatty acid may have better solubility of mastic. As compared with the oils and fats containing much amount of triglyceride, those having much amount of monoglyceride or diglyceride may have better solubility of mastic.
The anphipathic substance would mean the substance which is soluble both in water soluble ingredient and in oil soluble ingredient. This would cover, for example, surfactant, lower alcohol such as ethanol, and its aqueous solution.
The surfactant would mean those having the effects of emulsification, solubilization or dispersion between the water soluble substance and the oil soluble substance. This would cover, for example, soybean lecithin, egg yolk lecithin, soybean saponin, bile acid, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, cane sugar fatty acid ester, propylene glycol fatty acid ester.
Chitin, which is contained in large quantities in crustaceous animals such as crab, shrimp, krill, etc., would mean a natural polymer substance, as well as the hydrolysate thereof, consisting the b
Oliff & Berridg,e PLC
Page Thurman K.
Sansho Pharmaceutical Co., Ltd.
Sheikh Humera N.
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