Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-01-17
1993-04-13
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514445, 514517, 514534, 514550, 514551, 514552, 514710, 514712, 514821, 514913, 549 13, 549 62, 549 74, 549 80, 558 61, 558 62, 560 42, A61K 3138, C07D33308, C07C31300, C07C22900
Patent
active
052023478
ABSTRACT:
New soft .beta.-adrenergic blocking agents, useful in the treatment or prevention of cardiovascular disorders and in the treatment of glaucoma, have the formula ##STR1## wherein n is an integer from 0 to 10; R is C.sub.6 -C.sub.12 cycloalkyl-C.sub.p H.sub.2p --, C.sub.6 -C.sub.18 polycycloalkyl-C.sub.p H.sub.2p --, C.sub.6 -C.sub.18 polycycloalkenyl-C.sub.p H.sub.2p -- or C.sub.6 -C.sub.12 cycloalkenyl-C.sub.p H.sub.2p -- (wherein p is 0, 1, 2 or 3), or together with the adjacent ##STR2## group represents a variety of other complex ester groupings; R.sub.1 is C.sub.1 -C.sub.7 alkyl; and Ar is a divalent radical containing at least one aromatic nucleus. The corresponding pharmaceutically acceptable acid addition salts are also described.
REFERENCES:
patent: 3663607 (1972-05-01), Barrett et al.
patent: 3836671 (1974-09-01), Barrett et al.
patent: 4287194 (1981-09-01), Kosa et al.
patent: 4387103 (1983-06-01), Erhardt et al.
patent: 4438128 (1984-03-01), Wiedemann et al.
patent: 4454154 (1984-06-01), Matier
patent: 4578403 (1986-03-01), Matier
patent: 4703057 (1987-10-01), Marchand et al.
Bodor et al, Pharmaceutical Research, 1984, No. 3, 120-125.
Erhardt et al, J. Med. Chem., 1982, vol. 25, No. 12, 1408-1412.
Dees Jos,e G.
Nazhrio-Gonzalez Porfirio
LandOfFree
Soft .beta.-adrenergic blocking agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Soft .beta.-adrenergic blocking agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Soft .beta.-adrenergic blocking agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1155700