Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-04-26
1992-08-04
Gray, Bruce
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514212, 514218, 5142222, 5142268, 5142275, 5142288, 5142375, 514255, 514256, 514330, 514365, 514372, 514374, 514378, 514385, 514403, 514423, 514539, 514540, 540544, 540553, 540575, 540607, 544 3, 544 54, 544 584, 544 63, 544162, 544224, 544335, 544391, 546226, 548200, 548214, 548215, 548240, 548300, 548356, 548379, 548540, 560 42, C07C22900, A61K 3155
Patent
active
051359260
ABSTRACT:
New soft .beta.-adrenergic blocking agents, useful in the treatment or prevention of cardiovascular disorders and in the treatment of glaucoma, have the formula ##STR1## wherein n is an integer from 0 to 10; R is C.sub.6 -C.sub.12 cycloalkyl-C.sub.p H.sub.2p -, C.sub.6 -C.sub.18 polycycloalkyl-C.sub.p H.sub.2p -, C.sub.6 -C.sub.18 polycycloalkenyl-C.sub.p H.sub.2p - or C.sub.6 -C.sub.12 cycloalkenyl-C.sub.p H.sub.2p - (wherein p is 0, 1, 2 or 3), or together with the adjacent ##STR2## group represents a variety of other complex ester groupings; R.sub.1 is C.sub.1 -C.sub.7 alkyl; and Ar is a divalent radical containing at least one aromatic nucleus. The corresponding pharmaceutically acceptable acid addition salts are also described.
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Bodor et al, Pharmaceutical Research, 1984, No. 3, 120-125.
Erhardt et al, J. Med. Chem., 1982, vol. 25, No. 12, 1408-1412.
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