Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-06-27
2006-06-27
Ulm, John (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S069100, C435S252300, C435S320100, C435S091500, C435S023000
Reexamination Certificate
active
07067265
ABSTRACT:
The present invention discloses DNAs comprising nucleotide sequences set forth as SEQ ID NO:1 or NO:3 encoding Na+-driven Cl−/HCO3−exchanger, proteins comprising amino acid sequences set forth as SEQ ID NO:2 or NO:4, and their homologous proteins comprising an amino acid sequence having deletion, substitution, addition or insertion amino acids, which proteins, when expressed in a cell, functions as Na+-driven Cl−/HCO3−exchanger, and cells in which the proteins exogenously expressed.
REFERENCES:
patent: 6200776 (2001-03-01), Boron et al.
patent: 0892052 (1999-01-01), None
Database Em—Hum 'Online? EMBL; Dec. 2, 1998; Grichtchenko et al., “Homo Sapiens Sodium Bicarbonate Cotransporter (NBC) mRNA, complete CDs.” retrieved from EBI, accession No. AF069512, Database accession No. AF069512, XP002182615.
Database Swall 'Online?, May 1, 1999; Grichtchenko et al., “Sodium Bicarbonate Cotransporter” retrieved from EBI, accession No. 095233, Database accession No. 095233, XP002182616.
Grichtchenko et al., “Cloning Characterization, and Chromosomal Mapping of a Human Electroneutral Na+-driven CI-HC02 Exchanger”, The Journal of Biological Chemistry, vol. 276, No. 11, published Mar. 16, 2001, pp. 8358-8363, XP002182612.
Database EM—RO 'Online? EMBL; Apr. 5, 2000; Wang et al., “Mus musculus sodium bicarbonate cotransporter isoform 3 kNBC-2 mRNA”, retrieved from EBI, accession No. AF224508, Database accession No. AF224508, XP002182617.
Database Swall 'Online?, Oct. 1, 2000, Wang et al. “Sodium bicarbonate cotransporter isoform 3 INBC-3” retrieved from EBI, accession No. Q9JKV6, Database accession No. Q9JKV6, XP002182618.
Wang et al., “Mouse Na+:HC03-contransporter isoform NBC-2 (kNBC-3: Cloning, expression, and renal distribution” Kidney International, vol. 59, 2001, pp. 1405-1414, XP002182613.
Burnham et al., “Cloning and functional expression of a human kidney Na+: HC03-cotransporter”, The Journal of Biological Chemistry, vol. 272, No. 31, Aug. 1, 1997, pp. 19111-19114, XP002076894.
Database EM—RO 'Online? EMBL; Nov. 15, 22000; Wang et al., “Mus musculus SIc4a10 mRNA for NCBE, complete CDs.” retrieved from EBI, accession No. AB033759, Database accession No. AB033759, XP002182619.
Database Swall 'Online?; Mar. 1, 2001; Wang et al., “NCBE”, retrieved from EBI, accession No. Q9EST0, Database accession No. Q9EST0, XP002182620.
Database EM—HUM 'Online? EMBL; Nov. 21, 2000; Wang et al., “Homo sapiens SLC4A10 mRNA for NCBE, complete CDs” retrieved from EBI, accession No. AB040457, Database accession No. AB040457, XP002182621.
Database Swall 'Online?; Mar. 1, 2001; Wang et al., “NCBE”, retrieved from EBI, accession No. Q9HCQ6, Database accession No. Q9HCQ6, XP002182622.
Wang et al., “The Na+-driven CI-/HC03-exchanger”, The Journal of Biological Chemistry, vol. 275, No. 45, published Nov. 10, 2000, pp. 35486-35490, XP002182614.
Boron, W.F. et al., J. Exp. Biol., 200:263-268 (1997).
Pace, C.S. et al., J. Membrane Biol., 73:39-49 (1983).
Current Protocols in Molecular Biology, Edited by Ausubel, F.M. et al., John Wiley & Sons, Inc., vol. 1, Chapter 8: Mutagenesis of cloned DNA, pp. 8.0.1-8.5.10.
Vector Essential Data, Gacesa, P. and Ramji, D.P., BIOS Scientific Publishers Limited 1994, John Wiley & Sons in association with BIOS Scientific Publishers Ltd., Expression vectors, pp. 9-12.
Currrent Protocols in Molecular Biology, Edited by Ausubel, F.M. et al., John Wiley & Sons, Inc., vol. 1, Unit 1.8: Introduction of Plasmid DNA into Cells, pp. 1.8.1-1.8.10.
Current Protocols in Molecular Biology, Edited by Ausubel, F.M. et al., John Wiley & Sons, Inc., vol. 1, Chapter 9: Introduction of DNA into Mammalian Cells, pp. 9.0.1-9.17.3.
Current Protocols in Molecular Biology, Edited by Ausubel, F.M. et al., John Wiley & Sons, Inc., vol. 2, Chapter 11: Immunology, pp. 11.0.1-11.16.13.
Burnham, C.E. et al., J. Biol. Chem., 272:19111-19114 (1997).
Inagaki, N. et al., Proc. Natl. Acad. Sci. USA, 91:2679-2683 (1994).
Fukumoto, H. et al., Proc. Natl. Acad. Sci. USA, 85:5434-5438 (1988).
Wang, C.Z. et al., Biochem. Biophys. Res. Commun., 220:196-202(1996).
Thomas. J.A. et al., Zbiochemistry, 18:2210-2218 (1979).
Pushkin, A. et al., J. Biol. Chem., 274:16569-16575 (1999).
Ishibashi, K. et al., Biochem. Biophys. Res. Commun., 24:535-538 (1998).
Seino Susumu
Wang Changzheng
Yano Hideki
Greenblum & Bernstein P.L.C.
JCR Pharmaceuticals Co. Ltd.
Seino Susumu
Ulm John
LandOfFree
Sodium ion-driven chloride/bi-carbonate exchanger does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sodium ion-driven chloride/bi-carbonate exchanger, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sodium ion-driven chloride/bi-carbonate exchanger will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3698541