Sodium-independent transporter transporting small-sized...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Details

C435S069100, C435S069700, C435S252300, C435S320100, C536S023400, C536S023500

Reexamination Certificate

active

10490824

ABSTRACT:
The invention provides a sodium independent transporter which transports a small-sized neutral amino acid and its analog; its gene; fused proteins; and a method of analyzing the function of the transporter. Further provided is a use for the transporters as described by the invention.

REFERENCES:
patent: 2000-342270 (2000-12-01), None
patent: 2001-46070 (2001-02-01), None
patent: WO 00/14228 (2000-03-01), None
patent: WO 01/58944 (2001-08-01), None
A. Chairoungdua et al.,The Journal of Biological Chemistry, 276(52):49390-49399 (2001).
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R. Pfeiffer et al.,Mol. Biol. Cell., 10(12):4135-4147 (1999).
Database EMBL, “Mus Musculus 0 Day Neonate Kidney cDNA, RIKEN full-length enriched library, clone: D630003H08, 3′ end partial sequence”, XP002313135 (Jul. 19, 2000).
Database EMBL, “um30a03.×1 sugano mouse kidney mkia Mus musculus cDNA clone IMAGE: 2236012 3′similar to WP:Y53H1C.B CE22438; mRNA sequence”, XP002313136 (Oct. 21, 1999).
Chairoungdua A. et al. “Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain” Journal of Biological Chemisty, American Society of Biological Chemists, Baltimore, MD, US, vol. 276, No. 52, Dec. 2001, pp. 49390-49399, XP002960766, ISSN: 0021-9258.
Chairoungdua A. et al. “Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein” Journal of Biological Chemistry, American Society of Biological Chemists, Baltimore, MD, US, vol. 274, No. 41, Oct. 8, 1999, pp. 28845-28848, XP002941606, ISSN: 0021-9258.
Segawa H. et al. “Identification and functional characterization of a NA+-independent neutral amino acid transporter with broad substrate selectivity” Journal of Biological Chemistry, American Society of Biological Chemists, Baltimore, MD, US, vol. 274, No. 28, Jul. 9, 1999, pp. 19745-19751, XP002293829, ISSN: 0021-9258.
H. Segawa et al., “Cloning, functional expression and dietary regulation of the mouse neutral and basic amino acid transporter (NBAT)”, Biochem, J., vol. 328, pp. 657-664 (1997).
Y. Kanai et al., “Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)”, J. Biol. Chem., vol. 273, No. 37, pp. 23629-23632 (1998).

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