Sodium channel modulators

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S139000, C546S184000, C546S248000, C546S272700, C548S340100, C548S356100, C548S375100, C548S376100, C514S235800, C514S397000, C514S399000, C514S406000

Reexamination Certificate

active

06872741

ABSTRACT:
The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).

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patent: WO 9727169 (1997-07-01), None
De Luca et al., “Molecular Determinants of Mexiletine Structure for Potent and Use-Dependent Block of Skeletal Muscle Sodium Channels”, Molecular Pharmacology, vol. 57, pp 268-277 (2000).
Hunter et al., “Voltage-gated sodium channel blockers for the treatment of chronic pain”, Current Opinion in CPNS Investigational Drugs, vol. 1(1), pp 72-81 (1999).
Loughhead et al., “Synthesis of Mexiletiine Stereoisonomers and Related Compounds via SNAr Nucleophilic Substitution of a Cr(CO)3-Complexed Aromatic Fluoride”, J. Org. Chem., vol. 64, pp 3373-3375 (1999).
Madge, “Chapter 6. Sodium Channels: Recent Developments and Therapeutic Potential”, Annual Reports in Medicinal Chemistry, pp 51-59 (1998).
Roufos et al., “A Structure-Activity Relationship Study of Novel Phenylacetamides Which Are Sodium Channel Blockers”, J. Med. Chem., vol. 39, pp 1514-1520 (1996).

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