Sodium channel blockers

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Reexamination Certificate

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C560S041000, C562S405000, C562S433000, C562S489000, C564S123000

Reexamination Certificate

active

07439383

ABSTRACT:
The present invention is directed to novel phenytoin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be used to limit or prevent PCa growth and/or metastasis.

REFERENCES:
patent: 2366221 (1945-01-01), Spurlock
patent: 2526232 (1950-10-01), Henze
patent: 4258054 (1981-03-01), Sarges
patent: 5389614 (1995-02-01), König et al.
patent: 5463125 (1995-10-01), Sandoval et al.
patent: 2002/0156016 (2002-10-01), Minuk
patent: 0006407 (1980-01-01), None
patent: 0076957 (1983-04-01), None
patent: 0115133 (1984-08-01), None
patent: 0552631 (1993-07-01), None
patent: 980250 (1965-01-01), None
patent: 1566171 (1980-04-01), None
patent: 447401 (1974-10-01), None
patent: WO 99/41229 (1999-08-01), None
patent: WO 01/45704 (2001-06-01), None
patent: WO 02/083133 (2002-10-01), None
Grunewald et al , Tetrahedron Letters , 1980, 21 (13), p. 1219-1220 (a copy of abstract page ).
Desphande, R.N. et al., (1970), “Synthesis of Hydantoins of Pharmacological Interest,” Indian Journal of Chemistry, Section B: Organic, Incl. Medicinal, Publications & Informatioins Directorate, New Delhi, IN, vol. 8, No. 11, pp. 1043-1044.
Galvez, E. et al., (1983), “Synthesis and Structural Studey of Cyclopentane, Indene and Flourene Spiro-derivatives,” Journal of Heterocyclic Chemistry, Heterocorporation. Provo, US, vol. 20, No. 1, pp. 13-16.
Sarges, R. et al., (1987), “Spiro Hydantoin Aldose Redutase Inhibitors,” Journal of Medicinal Chemistry, vol. 31, No. 1, pp. 230-242.
Dupriest. M.T. et al., (1991), “Spiro[fluoreneisothiazolidin]one Dioxides: New Aldose Redutase and L-Hexonate dehydrogenase Inhibitors,” Journal of Medicinal Chemistry, vol. 34, No. 11, pp. 3229-3234.
Abdul, M. et al., (2001), “Inhibition by Anticonvulsants of Prostate-specifice Antigen and Interleukin-6 Secretion by Human Prostate Cancer Cells,” Anticancer Research, vol. 21, pp. 2045-2048.
Meza-Toledo, S.E. et al., (1995), “Stereoselective Anticonvulsant Activity of the Enantiomers of (.+−.)-2-Hydroxy-2-phenylbutyramide,” Arzneimittel Forschung. Drug Research, vol. 45, pp. 756-759.
Meza-Toledo, S.E. et al., (1990), “A New Homologous Series of Anticonvulsants: Phenyl Alcohol Amides,” Arzneimittel Forschung. Drug Research, vol. 40, pp. 1289-1291.
Wilimowski, M. et al., (1970), “Pharmacologic Properties of Derivatives of 3-Phenyl-3-Hydroxyglutaric Acid,” Archivum Immunologiae et Therapiae Experimentalis, vol. 18, pp. 270-279.
Barrio, J. et al., (1971), “5-Cyclohexylmethyl-5-arylhydantoins,” Journal of Medicinal Chemistry, vol. 14, No. 9, p. 898.
Brown, M.L. et al., (1999), “Comparative Molecular Field Analysis of Hydantoin Binding to the Neuronal Voltage-Dependent Sodium Channel,” J. Med. Chem., vol. 42, pp. 1537-1545.
Knabe, J. et al., (1997), “Razemate und Enantiomere basisch substituierter 5-Phenylhydantoine, Synthese und antiarrhythmische Wirkung, Racemates and enantiomers of basic substituted 5-phenylhydantoins, synthesis and antiarrhythmic activity,” Pharmazie, Die, Gopvi Verlag, Eschborn, De, vol. 52, pp. 912-919.
Casagrande, C. et al., (1974), “Synthesis and antiarrhythmic activity of 5,5-disubstituted-3-aminoalkylhydantoins and some heterocyclic and noncyclid analogues,” Farmaco, Edizione Scientifica, Societa Chemica Italiana, Pavia IT, vol. 29, No. 10, pp. 757-785.
Brouillette, W.J. et al., (1990), “Sodium channel binding and anticonvulsant activities of hydantoins containing conformationally constrained 5-phenyl substituents,” J. of Pharmaceutical Sciences, Am. Pharmaceutical Assoc. Washington, US, vol. 79, No. 10, pp. 871-874.
Kadam, A.N. et al., (1978), “Synthesis of gamma-(5-arylhydantoin-5)-butyric acids,” J. of the Indian Chemical Society, Calcutta, IN, vol. 51, No. 1, pp. 107-108.

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