SODD-specific antibodies and methods

Details SODD-specific antibodies and methods SODD-specific antibodies and methods

1999-10-08

2000-08-29

Eyler, Yvonne

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 723, 5303879, 53038822, G01N 3353, G01N 33574, C07K 1600, C12P 2108

Patent

active

061106909

ABSTRACT:
The invention provides methods and compositions relating to Suppressor of Death Domain (SODD) proteins which regulate cellular signal transduction and transcriptional activation, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed SODD encoding nucleic acids or purified from human cells. The invention provides isolated SODD hybridization probes and primers capable of specifically hybridizing with the disclosed SODD genes, SODD-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

REFERENCES:
Schiffmann, S. et al. Isolation of cDNA clones encoding adenosine-5'-phosphosulfate-kinase (EC 2.7.1.25) and an Isoform (akn2) from Arabidopsis (Accession No. AF043351). Plant Physiology. Jan. 1998, vol. 117, No. 3, p. 1125, esp p. 1125.
Arz, H.E. et al. A cDNA for Adenyl Sulphate (APS) -kinase from Arabidopsis thaliana: Biochimica et Biophysica Acta. 1994, vol. 1218, No. 3, pp. 447-452 esp p. 449.

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