Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-12-02
2000-07-18
Carlson, Karen Cochrane
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
530358, 530350, 514 2, G01N 3353, G01N 3718, G01N 100, G01N 3816
Patent
active
060905646
ABSTRACT:
The present invention provides novel human small nuclear ribonucleoprotein (snRNP) Sm proteins (collectively called HSMP) and polynucleotides which identify and encode HSMP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HSMP. The invention also provides pharmaceutical compositions containing HSMP or antagonists to HSMP, and in the use of these compositions for the treatment of diseases associated with the expression of HSMP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HSMP for the treatment of diseases associated with the expression of HSMP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding HSMP or anti-HSMP antibodies which specifically bind to HSMP.
REFERENCES:
Hermann et al. snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions. EMBO J. 14(9): 2076-2088, 1995.
Lerner, M.R., et al., "Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus", Proc. Nat. Acad. Sci., 76:5495-5499 (1979).
Raker, V.A., et al., "The snRNP core assembly pathway: identification of stable core protein heteromeric complexes and an snRNP subcore particle in vitro", EMBO J., 15:2256-2269 (1996).
Seraphin, B., "Sm and Sm-like proteins belong to a large family: identification of proteins of the U6 as well as the U1, U2, U4 and U5 snRNPs", EMBO J., 14:2089-2098 (1995).
Hermann, H., et al., "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions", EMBO J., 14:2076-2088 (1995).
Wilson, R., et al., "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans", Nature, 368:32-38 (1994).
Van Dyck, L., et al., "Analysis of a 17.4 kb DNA Segment of Yeast Chromosome II Encompassing the Ribosomal Protein L19 as well as Proteins with Homologies to Components of the hnRNP and snRNP Complexes and to the Human Proliferation-associated p120 Antigen", Yeast, 10:1663-1673 (1994).
Tomer, Y., et al., "Pathogenic Significance and Diagnostic Value of Lupus Autoantibodies, ", Int Arch Allergy Immunol, 100:293-306 (1993).
Grgacic, E., et al., "Cell-mediated immune response to copolymer I in multiple sclerosis measured by the macrophage procoagulant activity assay", Int. Immunol, 2:713-718 (1990).
Teitelbaum, D., et al., "Copolymer 1 inhibits chronic relapsing experimental allergic encephalomyelitis induced by proteolipid protein (PLP) peptides in mice and interferes with PLP-specific T cell responses", J. Neuro., 64:209-217 (1996).
Mallet, L., (GI 1078051), GenBank Sequence Database (Accession 1078051), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Rokeach, L.A. et al., "Molecular cloning of a cDNA encoding the human Sm-D autoantigen", Proc. Natl. Acad. Sci. USA, 85: 4832-4836 (1988).
Wagatsuma, M. et al. "Antibody Recognition of the Recombinant Human Nuclear Antigens RNP 70 kD, SS-A, SS-B and Sm-D by Autoimmune Sera", Molecular Immunology, 30: 1491-1498 (1993).
Hirt, H. et al., "An alfalfa cDNA encodes a protein with similarity to human snRNP-E" Nucleic Acids Research, 20(3): 613 (1992).
Rymond, B.C., "Convergent transcripts of the yeast PRP38-SMD1 locus encode two essential splicing factors, including the D1 core polypeptide of small nuclear ribonucleoprotein particles", Proc. Natl. Acad. Sci. USA, 90: 848-852 (1993).
Reichlin, M. et al., "Lupus Autoantibodies to Native DNA Cross-React with the A and D SnRNP Polypeptides", J. Clin. Invest., 93: 443-449 (1994).
Bandman Olga
Hillman Jennifer L.
Zweiger Gary B.
Carlson Karen Cochrane
Incyte Pharmaceuticals Inc.
Schnizer Holly
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