Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1987-12-22
1988-09-27
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530325, 530326, 530856, C07G 700, A61K 3702
Patent
active
047743182
ABSTRACT:
Novel cytotoxic agents are provided as small polypeptides related to a low molecular weight peptide derived from Crotalus atrox. The compounds may be used by themselves or in combination with other reagents, such as antibodies, for inhibiting cell growth.
REFERENCES:
Maeda et al, "Some Chemical Properties of the Venom of the Rattlesnake, Crotalus Viridis Helleri", Toxicon, vol. 16, pp. 431-441, 1978.
Laure, "Die Primarstruktur des Crotamine", Hoppe-Seyler's Z. Physiol. Chem. Bd. 356 S. 213-215, Feb./1975.
Marquardt Hans
Todaro George J.
Twardzik Daniel R.
Nutter Nathan M.
Oncogen
Phillips Delbert R.
Rowland Bertram I.
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