Snake venom growth arresting peptide

Details Snake venom growth arresting peptide Snake venom growth arresting peptide

1985-11-22

1988-03-15

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530350, 530403, 530405, 530856, 514 12, 514 2, 514 21, 424 85, A61K 3702, C07G 700

Patent

active

047314397

ABSTRACT:
Novel cytotoxic agents are provided as small polypeptides related to a low molecular weight peptide derived from Crotalus atrox. The compounds may be used by themselves or in combination with other reagents, such as antibodies, for inhibiting cell growth.

REFERENCES:
patent: 4220722 (1980-09-01), Rowley et al.
patent: 4221777 (1980-09-01), Nishino
patent: 4340535 (1982-07-01), Voisin et al.
patent: 4500637 (1985-02-01), Neville, Jr. et al.
Masuho et al., "Preparation of a Hybrid of Fragment Fab' of Antibody and Fragment A of Diphtheria Toxin and its Cytotoxicity", vol. 90, No. 1, 1979, Sep. 12, 1979, Biochem. and Biophys. Res. Comm., pp. 320-326.
Maeda et al., "Some Chemical Properties of the Venom of the Rattlesnake", Crotalus Viridis Helleri, Toxicon, vol. 16, pp. 431-441, 1978.
Laure, "Die Primarstruktur des Crotamins", Hoppe-Seyler's Z. Physiol. Chem. Bd. 356, S. 213-215, Feb. 1975.

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