Smooth muscle relaxation

Details Smooth muscle relaxation Smooth muscle relaxation

2011-08-02

2011-08-02

Henley, III, Raymond (Department: 1629)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S551000, C514S561000, C514S575000, C514S626000

Reexamination Certificate

active

07989420

ABSTRACT:
The invention relates to methods of inducing smooth muscle relaxation, for example, a method of inducing relaxation of a vascular or a non-vascular muscle or a method of inducing relaxation of the microvasculature, in a subject in need thereof by promoting the accumulation of protoporphyrin IX in the smooth muscle.

REFERENCES:
patent: 5026825 (1991-06-01), Grebow
patent: 5369142 (1994-11-01), Culbertson
Mingone C. J. et al., Protoporphyrin IX generation from δ-aminolevulinic acid elicits pulmonary artery relaxation and soluble guanylate cyclase activation, 2006, Am. J. Physiol. Lung Cell. Mol. Physiol. 291:L337-344.
Herman M.A., et al., Hemodynamic effects of 5-aminolevulinic acid humans, 1998, Journal of Photochemistry and Photobiology B: Biology, 43:61-65.
Nyamekye I. et al., Phtodynamic Therapy of Normal and Balloon-Injured Rat Carotid Arteries Using 5-Amino-Levulinic Acid, 1995, Circulation, 91:417-425.
Mingone C. J. et al., Protoporphyrin IX generation from δ-aminolevulinic acid elicits pulmonary artery relaxation and soluble guanylate cyclase activation, 2006,The FASEB Journal, 20:A400-d.
Search Report and Written Opinion for PCT/US07/007008, (2007).

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