Smooth muscle mitogen and isolated DNA coding therefor

Details Smooth muscle mitogen and isolated DNA coding therefor Smooth muscle mitogen and isolated DNA coding therefor

1998-03-27

2000-01-11

Teng, Sally P.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

530350, 435 691, C07K 1400

Patent

active

060137622

ABSTRACT:
A recombinant non-glycosylated mammalian growth factor (BTC-GF) stimulates proliferation of human smooth muscle cells. Especially, the amino acid sequence of the protein deduced from the nucleotide sequence coding for human BTC-GF is as that comprising the amino acids No. 1 to No. 147 of FIG. 10 (SEQ ID NO:18) or the amino acids No. 1 to 80 of FIG. 10, (SEQ ID NO:18) and the amino acid sequence of the protein deduced from the nucleotide sequence coding for mouse BTC-GF is as that comprising the amino acids No. 1 to No. 146 of FIG. 9 (SEQ ID NO:17).

REFERENCES:
patent: 5328986 (1994-07-01), Folkman et al.
Tarentino et al., Journal of Biological Chemistry, 249, 818-824, Feb. 10, 1974.
ATCC Catalogue of Cell Lines & Hybridomas, Seventh Edition 1992, p. 162, ATCC CRL 1682 and 1687.

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