Smooth muscle cell LIM protein

Details Smooth muscle cell LIM protein Smooth muscle cell LIM protein

1996-03-15

1998-06-16

Chambers, Jasemine C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 2431, 4351723, 435 691, 435325, 435 912, 514 44, 935 23, C12N 1512

Patent

active

057672628

ABSTRACT:
A substantially pure DNA comprising a sequence encoding a smooth muscle cell LIM (SmLIM) polypeptide, methods of diagnosing vascular injury by detecting a decrease in SmLIM gene expression, and methods of inhibiting vascular smooth muscle cell proliferation.

REFERENCES:
Weiskirchen et al., Oncogene, vol. 8, pp. 2317-2324, 1993.
Hillier et al., GenBank Accession #N39473, Jan. 19, 1996.
Arber et al., "Muscle LIM Protein, a Novel Essential Regulator of Myogenesis, Promotes Myogenic Differentiation", Cell, 79:221-31 (1994).
Crawford et al., "Biochemical and Molecular Characterization of the Chicken Cysteine-rich Protein, a Developmentally Regulated LIM-Domain Protein That Is Associated with the Actin Cytoskeleton", J. Cell Biol., 124:117-27 (1994).
Libby et al., "Biology of Disease: Involvement of the Immune System in Human Atherogenesis: Current Knowledge and Unanswered Questions", Lab. Investig., 64:5-15 (1991).
Munro et al., "Biology of Disease: The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation", Lab. Invest., 58:249-61 (1988).
Ross, "The Pathogenesis of Atherosclerosis: a Perspective for the 1990s", Nature, 362:801-809 (1993).
Sadler et al., "Zyxin and cCRP: Two Interactive LIM Domain Proteins Associated with the Cytoskeleton", J. Cell Biol., 119:1573-87 (1992).
Tsai et al., "Promotion of Vascular Smooth Muscle Cell Growth by Homocysteine: A Link to Atherosclerosis", PNAS USA, 91:6369-73 (1994).
Tsai et al., "Induction of Cyclin A Gene Expression by Homocysteine in Vascular Smooth Muscle Cells", J. Clin. Invest., 97:146-53 (1996).
Wang et al., "Analysis of the Human Cysteine-Rich Protein Gene (CSRP) Assignment to Chromosome 1q24-1q32, and Identification of an Associated Mspl Polymorphism", Genomics, 14:391-97 (1992).
Wang et al., "Human Cysteine-rich Protein: A Member of the Lim/Double-Finger Family Displaying Coordinate Serum Induction with c-myc", J. Biol. Chem., 267:9176-84 (1992).
Warren et al., "The Oncogenic Cysteine-Rich LIM Domain Protein Rbtn2 is Essential for Erythroid Development" Cell, 78:45-57 (1994).
Weiskirchen et al., "The Cysteine-rich Protein Family of Highly Related LIM Domain Proteins", J. Biol. Chem. 270:28946-54 (1995).

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