Smallpox monoclonal antibody

Details Smallpox monoclonal antibody Smallpox monoclonal antibody

2007-08-22

2010-10-12

Rawlings, Stephen L (Department: 1643)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C530S350000, C530S387100, C530S387300, C530S388100, C530S388300, C530S387900, C424S133100, C424S159100, C424S139100, C536S023500, C435S069100, C435S320100, C435S325000, C435S339000, C435S331000

Reexamination Certificate

active

07811568

ABSTRACT:
Humanized monoclonal antibodies against the vaccinia virus B5R surface antigen. The antibodies are effective in treating smallpox infection. Also disclosed are nucleic acids that encode the heavy and light chains of such antibodies and cells that express them.

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Lustig et al., “Combinations of Polyclonal or Monoclonal Antibodies to Proteins of the Outer Membranes of the Two Infectious Forms of Vaccinia Virus Protect Mice against a Lethal Respiratory Challenge,” Journal of Virology, 79(21):13454-13462 (2005).
Ramirez et al., “Administration to Mice of a Monoclonal Antibody that Neutralizes the Intracellular Mature Virus Form of Vaccinia Virus Limits Virus Replication Efficiently under Prophylactic and Therapeutic Conditions,” Journal of General Virology, 83:1059-1067 (2002).
Schmelz et al., “Assembly of Vaccinia Virus: The Second Wrapping Cisterna Is Derived from the Trans Golgi Network,” Journal of Virology, 68(1):130-147 (1994).
Bell et al., “Antibodies against the Extracellular Enveloped Virus B5R Protein are Mainly Responsible for the EEV Neutralizing Capacity of Vaccinia Immune Globulin,”Virology. 01 vol. 325, No. 2, pp. 425-431; see entire document (e.g., the abstract), 2004.
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