Small scale NMR spectroscopic apparatus and method

Electricity: measuring and testing – Particle precession resonance – Spectrometer components

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G01V 300

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06163154&

ABSTRACT:
A magnet assembly for a small scale NMR spectroscopy apparatus suitable for laboratory or home use, generally comprising two permanent magnets facing one another so that the facing surfaces have opposite polarities, a pole cap on each of the two facing surfaces of the permanent magnets, and a plurality of radially polarized canceling magnets disposed about the permanent magnets and pole caps. The design and position of the radially polarized canceling magnets about the tapered pole caps reduces leakage of the magnetic field, to maintain the magnetic field strength and homogeneity within the test region, without a disadvantageous increase in the size, weight and cost of the NMR apparatus. A curved edge ring shim may be used to increase magnetic field homogeneity in the test region. Also provided is a method for measurement of glucose concentration in a fluid using NMR spectroscopy. In one aspect of the invention the fluid is a patient's body fluid and the invention provides for in vivo measurement of the glucose concentration. The method comprises spectral editing in which a RF pulse sequence is used to isolate desired resonances of glucose and thereby facilitate resolution of the glucose signal.

REFERENCES:
patent: 3017544 (1962-01-01), Kane et al.
patent: 3182231 (1965-05-01), Gang et al.
patent: 3325757 (1967-06-01), Gang
patent: 3358676 (1967-12-01), Frei et al.
patent: 3434085 (1969-03-01), Gang
patent: 3437963 (1969-04-01), Gang et al.
patent: 3467076 (1969-09-01), Frisch et al.
patent: 3474222 (1969-10-01), Gang
patent: 3768054 (1973-10-01), Neugebauer
patent: 4134395 (1979-01-01), Davis
patent: 4325089 (1982-04-01), Hsu
patent: 4534358 (1985-08-01), Young
patent: 4590947 (1986-05-01), Krause
patent: 4593384 (1986-06-01), Kleijne
patent: 4608991 (1986-09-01), Rollwitz
patent: 4635643 (1987-01-01), Brown
patent: 4667176 (1987-05-01), Matsuda
patent: 4672346 (1987-06-01), Miyamoto et al.
patent: 4674513 (1987-06-01), Jasper, Jr.
patent: 4677383 (1987-06-01), Ohuchi
patent: 4684889 (1987-08-01), Yamaguchi et al.
patent: 4777464 (1988-10-01), Takabatashi et al.
patent: 4839059 (1989-06-01), Leupold
patent: 4875486 (1989-10-01), Rapoport et al.
patent: 4937545 (1990-06-01), Chaillout et al.
patent: 4994777 (1991-02-01), Leupold et al.
patent: 4998976 (1991-03-01), Rapoport
patent: 5036279 (1991-07-01), Jonsen
patent: 5055812 (1991-10-01), Abele et al.
patent: 5089798 (1992-02-01), Miyata
patent: 5095271 (1992-03-01), Ohlawa
patent: 5132230 (1992-07-01), Rosenthal et al.
patent: 5231031 (1993-07-01), Szwergold et al.
patent: 5233991 (1993-08-01), Wright
patent: 5250284 (1993-10-01), Krongrad
patent: 5320103 (1994-06-01), Rapoport et al.
patent: 5390673 (1995-02-01), Kikinis
patent: 5398681 (1995-03-01), Kuperschmidt
patent: 5433196 (1995-07-01), Fiat
patent: 5495222 (1996-02-01), Abele et al.
patent: 5565834 (1996-10-01), Hanley et al.
patent: 5592086 (1997-01-01), Weinstock et al.
patent: 5657758 (1997-08-01), Posse et al.
patent: 5676143 (1997-10-01), Simonsen et al.
patent: 5685300 (1997-11-01), Kuenstner
patent: 5752512 (1998-05-01), Gozani
patent: 5755665 (1998-05-01), Takahaski et al.
patent: 5771893 (1998-06-01), Kassai et al.
Chen et al. "Localized .sup.1 H NMR measurement of glucose consumption in the human brain during visual stimulation" Proc. Natl. Acad. Sci. USA 90:9896-9900 (1993).
Merboldt et al. "Decrease of Glucose in the Human Visual Cortex during Photic Stimulation" Magnetic Resonance in Medicine 25:187-194 (1992).
Gruetter et al. "Detection and Assignment of the Glucose Signal in .sup.1 H NMR Difference Spectra of the Human Brain" Magnetic Resonance in Medicine 27:183-188 (1992).
Gruetter et al. "Direct measurement of brain glucose concentrations in humans by .sup.3 C NMR spectroscopy" Proc. Natl. Acad. Sci. USA 89:1109-1112 (1992).
Schupp et al. "Localized Detection of Glioma Glycolysis using Edited .sup.1 H MRS" Magnetic Resonance Research in Medicine 30:18-27 (1993).
P.C.M. van Zijl "In vivo detection of 1-.sup.13 C)-glucose and its metabolic products with proton sensitivity and carbon resolution" SMRM Abstracts 11th Annual Meeting (1992).
Bruhn et al. "Proton MRS of Cerebral Glucose in Patients with Diabetes Mellitus" SMRM Abstracts 10th Annual Meeting (1991).
Roland Kreis and Brian Ross "Diabetes Mellitus: Cerebral metabolic abnormalities detected by localised .sup.1 H-MRS" SMRM Abstracts 10th Annual Meeting (1991).
Michaelis et al. "Quantification of Cerebral Metabolites in Man. Results Using Short-Echo Time Localized Proton MRS" SMRM Abstracts 10th Annual Meeting (1991).
Behar "Separation of Macromolecules from Metabolites in the .sup.1 H NMR Spectrum of Brain" SMRM Abstracts 10th Annual Meeting (1991).
Barker et al. "Quantitation of .sup.1 H NMR Spectra of the Human Brain" SMRM Abstracts 10th Annual Meeting (1991).
Provencher "Estimation of Metabolite Concentrations from Localized in Vivo Proton NMR Spectra" Magnetic Resonance in Medicine 30:672-679 (1993).
X. Miao et al. "A Homonuclear Equivalent of the INEPT Experiment. Simplification of Crowded Proton Spectra and Measurement of Unresolved Couplings" J. Magn. Reson. Series A(117):128-131 (1995).
Hore et al. "Multiplet Selection in Crowded .sup.1 H NMR Spectra via Double Quantum Coherence" J. Amer. Chem. Soc. 104:4286-4288 (1982).
Mason et al. "Glutathione in whole blood: a novel determination using double quantum coherence transfer proton NMR spectroscopy" Federation of European Biochemical Societies 318:30-34 (1993).
Anderson, W.A. Electrical Current Shims for correcting Magnetic Fields, The Review of Scientific Instruments vol. 32, No. 3 pp. 241-250, Mar. 1961.
Merriam Webster's Collegiate College Dictionary Tenth Edition pp. 14, 47, 109, 335, and 1245 1997 no month.
Bushong, Stewart C. Magnetic Resonance Imaging Physical and Biological Principles Second Edition textbook Mosby New York Chapter 11 pp. 128-143 no month, 1996.
Varian Brochure "The EM-360A NMR Spectrometer, low cost, high resolution 60-MHz NMR system" (No Date).
Varian Brochure "The EM-390 NMR Spectrometer, low cost, high performance 90-MHz NMR system" (No Date).

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