Small peptides which inhibit binding to T-4 receptors and act as

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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4241881, 514 17, 530328, 530329, 530330, A61K 3804, A61K 3808

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058344292

ABSTRACT:
Short peptide of the formula:

REFERENCES:
patent: 4629783 (1986-12-01), Cosand
patent: 4737487 (1988-04-01), Watts et al.
Ray Sanchez-Pescador et al. Nucleotide Sequence and Expression of an AID-Associated Retrovirus (ARV-2), Science, vol. 227: pp. 484-492 (1985).
Candace B. Pert, Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T-cell infectivity. Proc. Natl. Acad. Sci. USA, vol. 83, pp. 9254-9258, (Dec. 1986).
J. A. Parsons, Biological Council, The Co-ordinating Committee for Symposia on Drug Action, Peptide Hormones, Jun. 1976.
Edward S. Golub, The Cellular Basis of the Immune Response, an approach to Immunobiology. Sinaurer Associates, Inc., Sunderland, MA, pp. 81-82 (1981).
Angus G. Dalgleish et al. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature, vol. 312, 20/27, pp. 763-767, Dec. 1984.
Bruno R. Starcich, et al. Identification and Characterization of Conserved and Variable Regions in the Envelope Gene of HTLV-III/LAV, the Retrovirus of AIDS, Cell, vol. 45, pp. 637-648 (1986).
Ratner, et al. Complete nucleotide sequence of the AIDS virus, HTLV-III, Nature, vol. 313, pp. 277-284 (1985).
The Lancet, Improvement in AIDS Patients on Peptide T, Boston Mass. and London, Saturday Jul. 22, 1989, vol. II for 1989, No. 8565.
MacFadden et al, Role of Peptide T in Palliation of HIV-1-Related Painful Peripheral Neuropathy, VIIth Int'l conference on AIDS, Florence, 1991;W.B. 2173. (Unpublished).
Brenneman et al. Acquired Immune Deficiency Syndrome and the developing Nervous System, International Review of Neurobiology, vol. 32, pp. 305 353, 1990.
Phase I Studies of Peptide T for the Neuropsychiatric Complications of HIV Infection, Immunology Virology Pharmacokinetics, Studies performed at the University of California School of Medicine, Nov. 1989, (Unpublished).
Investigators Brochure, D-Ala 1-Peptide-T-Amide, (Peptide T) Integra Institute, Bethesda, MD, pp. 1-3. (Unpublished).
Julander et al, Treatment of HIV-1 infected patients with peptide T, Antiviral Chemistry & Chemotherapy, vol. 1(6), pp. 349-345, (Jan. 1991).
Abstracts of Peptide T Clinical Results, Vth International Conference on AIDS, Montreal, Jun. 4-9, 1989, (Unpublished).
Ruff et al, Pharmacokinetics of Peptide T in Patients with Acquired Immunodeficiency Syndrome (AIDS), Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1991, vol. 15, pp. 791-799.
Mayer et al, A Phase I Study of Intranasal Peptide T for the Treatment of Symptomatic HIV-Infected Patients: Clinical and Laboratory Results, Running Head: Intranasal Peptide T in HIV Infection, pp. 1-24, (Unpublished).
Buzy, et al, Potent gp120-like neurotoxic activity in the cerebrospinal fluid of HIV-infected individuals, Brain Research, 1992, pp. 1-9.
Bridge, et al; Neuropsychiatric Outcome in HIV Dementia to Peptide T. (Unpublished).
Bridge et al, Results of Extended Peptide T Administration in AIDS and ARC Patients, Psychopharmacology Bulletin, vol. 27, No. 3, 1991, pp. 237-245.
Rosen, et al, Peptide T Treatment of Cognitive Impairment in HIV + Intravenous Drug Users, The American Journal on Addictions, vol. 1 (4), Fall 1992, pp. 332-338.
Bridge et al, Neuropsychologic Results of Controlled Trial of Peptide T in HIV-1, pp. 1-15. (Unpublished).
Virology Report, Pharmacology of Peptide T inhibition of in vito HIV infection. (Unpublished).
Peptide T Clinical Reports. Clinical Summary A Phase I Trial of Intranasal Peptide T: Safety, Toxicity and Pharmacokinetics in Human Immunodeficiency Virus 1 (HIV-1) Infected Patents. 1987-88, NIMH/USC, Los Angeles. (Unpublished).
Appendix I: Preliminary Studies. (Unpublished).
Appendix II. Neuropsychological Assessment, pp. 1-23. (Unpublished).
AZT, AZT Placebo, and Peptide T, Neuropsychologic Test Z Scores AIDS and ARC Patents.
Fenway Clinic Trial EEG Report, New York Medical College, Dec. 17, 1990. (Unpublished).
Peptide T. Clinical Trials, 1987-88, NIMH/USC, Los Angeles. (Unpublished).
Peptide T Clinical Trials, 1986-87, Karolinska Institute. (Unpublished).
Neuropsychologic Testing Results Fenway Community Health Center Phase One Study Peptide T, IND BB-2535, Oct. 29, 1990.
Fahcy et al., "Status of Immune-based Therapies in HIV Infection and AIDS," Clin. Exp. Immunol. 88:1-5, 1992.
Fox, J.L., "No Winners Against AIDS," Bio/Technology 12:128, Feb. 1994.
Rudinger, Peptide Hormone, Parsons (Ed), U Park Press, Baltimore, pp. 1-7 (1976).
Fauci, Proc. Natl. Acad. Sci, USA, vol. 83, pp. 9278-9283, (1986).
McClure et al., Current Topics in AIDS: vol. 1, Gottlieb et al. (Eds), John Wiley & Sons, New York, pp. 95-117 (1987).
Pert et al., Proc. Natl. Acad. Sci. USA, vol. 83, pp. 9254-9258, (1986).
Ruff et al., FEB, vol. 211, No. 1, pp. 17-22 (Jan. 1987).
Wettergberg et al., The Lancet p. 159 (Jan. 1987).
Robins, Immunology in Plant Sciences, Linskens et al. (Eds), Springer-Verlag, New York, pp. 86-141 (1986).
Cram et al., Organic Chemistry, 2.sup.nd edition, McGraw-Hill Book Company, pp. 607-613 (1964).
Lehninger, Principles of Biochemistry, Anderson et al. (Eds), Worth Publishers, Inc. New York, pp. 95-117 (1982).

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