Small peptides which inhibit binding to T-4 receptors and act as

Details Small peptides which inhibit binding to T-4 receptors and act as Small peptides which inhibit binding to T-4 receptors and act as

1990-08-16

1994-01-04

Chan, Y. Christina

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 16, 514 17, 514 18, 514885, 530328, 530329, 530330, A61K 3702, C07K 706

Patent

active

052760162

ABSTRACT:
Short peptide of the formula:

REFERENCES:
patent: 4737487 (1988-04-01), Watts et al.
Chakrabarti et al, Nature, vol. 320, pp. 535-537 (Apr. 1986).
Sanchez-Pescador et al, Science, vol. 227, pp. 484-492(1985).
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Pert et al, Proc. Natl. Acad. Sci. USA vol. 83 pp. 9254-9258 (Dec. 1986).
Ruff et al., FEB vol. 211, No. 1, pp. 17-21 (Jan. 1987).
Rudinger, Peptide Hormones, Parsons (Ed.), U. Park Press. Baltimore, pp. 1-7 (1976).
Fanci, PNAS USA vol. 83, pp. 9278-9283 (Dec. 1986).
Golub, The Cellular Basis of the Immune Response, second Edition, Sinauer Associates, Inc. Sunderland, Mass., pp. 81-82 (1981).
Cram et al., Organic Chemistry, 2nd Edition, McGraw-Hill Book Company, New York, pp. 607-613 (1964).
Lehninger, Principles of Biochemistry, Worth Publishers, Inc., New York pp. 95-117 (1982).
Mildvan et al., Current Topics in AIDs, vol. 1, Gottlieb et al., (Ed.), John Wiley & Sons, New York, pp. 31-45 (1987).
McClure et al., Current Topics in AIDs, vol. 1, Gottlieb et al, (Ed.), John Wiley & Sons, New York, pp. 95-117 (1987).
Bridge et al, Results of Extended Peptide T Administration in AIDS and ARC Patients, Psychopharmacology Bulletin, vol. 27, No. 3, 1991, pp. 237-245.
Rosen et al, Peptide T Treatment of Cognitive Impairment in HIV+ Intravenous Drug Users, The American Journal on Addictions, vol. 1(4), Fall 1992, pp. 332-338.
Buzy et al, Potent gp120-like neurotoxic activity in the cerebrospinal fluid of HIV-infected individuals, Brain Research, 1992, pp. 1-9.
Julander et al, Treatment of HIV-1 infected patients with peptide T, Antiviral Chemistry & Chemotherapy, 1990, vol. 1(6), pp. 349-354.
Ruff et al, Pharmacokinetics of Peptide T in Patients with Acquired Immunodeficiency Syndrome (AIDS), Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1991, vol. 15, pp. 791-799.
Brenneman et al, Acquired Immune Deficiency Syndrome and the Developing Nervous System, International Review of Neurobiology, vol. 32, pp. 305-353, 1990.
The Lancet, Improvement in AIDS Patients on Peptide T, Boston Mass. and London, Saturday Jul. 22, 1989, vol. II for 1989, No. 8656.
The Lancet, Hepatotoxicity of Cyclosporin in a Patient Given Nordette, Jan. 17, 1987, p. 159.
MacFadden et al, Role of Peptide T in Palliation of HIV-1-Related Painful Peripheral Neuropathy, VIIth Int'l Conference on AIDS, Florence, 1991: W.B. 2173. (Unpublished).
Phase I Studies of Peptide T for the Neuropsychiatric Complications of HIV Infection, Immunology Virology Pharmacokinetics, Studies performed at the University of California School of Medicine, Nov. 1989. (Unpublished).
Investigator's Brochure, D-Ala l-Peptide-T-Amide, (Peptide T) Integra Institute, Bethesda, MD, pp. 1-3. (Unpublished).
Abstracts of Peptide T Clinical Results, Vth International Conference on AIDS, Montreal, Jun. 4-9, 1989, (Unpublished).
Mayer et al, A Phase I Study of Intranasal Peptide T for the Treatment of Symptomatic HIV-Infected Patients: Clinical and Laboratory Results, Running Head: Intranasal Peptide T in HIV Infection, pp. 1-24. (Unpublished).
Bridge et al, Neuropsychiatric Outcome in HIV Dementia to Peptide T. (Unpublished).
Bridge et al, Neuropsychologic Results of Controlled Trial of Peptide T in HIV-1, pp. 1-15. (Unpublished).
Virology Report, Pharmacology of Peptide T inhibition of in vitro HIV infection. (Unpublished).
Roffman, A Phase I Trial of Intranasal Peptide T: Safety, Toxicity and Pharmacokinetics in Human Immunodeficiency Virus 1 (HIV-1) Infected Patients, International Drug Development Corporation. (Unpublished).
Appendix I, Preliminary studies. (Unpublished).
Appendix II. Neuropsychological Assessment, pp. 1-23. (Unpublished).
Fenway Clinic Trial EEG Report, New York Medical College, Dec. 17, 1990. (Unpublished).
Peptide T Clinical Trials, 1987-88, NIMH/USC, Los Angeles. (Unpublished).
Peptide T Clinical Trials, 1986-87, Karolinska Institute. (Unpublished).
Neuropsychologic Testing Results Fenyway Community Health Center Phase one Study Peptide T, Ind BB-2535, Oct. 29, 1990. (Unpublished).

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