Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1997-09-23
2000-07-18
Bawa, Raj
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424 45, 514938, A61K 9127, A61K 912
Patent
active
060904070
ABSTRACT:
The small particle liposome or lipid complex aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes or other lipid complexes. The liposomes and complexes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.
REFERENCES:
patent: 5552156 (1996-09-01), Burke
patent: 5736156 (1998-04-01), Burke
Gilbert Brian
Knight J. Vernon
Koshkina Nadezhda
Waldrep J. Clifford
Adler Benjamin Aaron
Bawa Raj
Research Development Foundation
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