Small particle formation

Details Small particle formation Small particle formation

1984-06-15

1986-08-19

Lovering, Richard D.

Coating processes

Particles, flakes, or granules coated or encapsulated

Solid encapsulation process utilizing an emulsion or...

252303, 2523635, 424 31, 514962, 514965, B01J 1302

Patent

active

046069399

ABSTRACT:
The present invention is concerned with the simultaneous formation and encapsulation of small particles of organic compounds whose solubility in water is greater at a first pH than at a second pH by concurrently precipitating said organic compounds as small particles and forming a coacervate of an anionic (or cationic) surfactant and an amphoteric surfactant. The process is preferably used to prepare a readily soluble encapsulated pharmaceutically active compound.

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Chih-Ming James Chen: "Production of Drugs in Small Particle Form", Dissertation, The Ohio State University, 1981.

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