Chemistry: analytical and immunological testing – Involving production or treatment of antibody
Patent
1996-05-23
1998-03-17
Achutamurthy, Ponnathapura
Chemistry: analytical and immunological testing
Involving production or treatment of antibody
5303915, 5303911, 5303913, 5303917, 4241781, 4241791, G01N 3353, C07K 1600, A61K 39395
Patent
active
057285900
ABSTRACT:
Small organometallic probes are disclosed which include a core of metal atoms bonded to organic moieties. The metal atoms are gold, silver, platinum, palladium, or combinations thereof. In one embodiment, a multifunctional organometallic probe is disclosed which includes a core of metal atoms surrounded by a shell of organic moieties covalently attached to the metal atoms, a fluorescent molecule, e.g., fluorescein, covalently attached to one of the organic moieties, and a targeting molecule, e.g., an antibody, covalently attached to another of the organic moieties. In another embodiment, a small metal cluster of palladium or platinum is disclosed in which the central metal core comprises platinum or palladium in which the central metal core is from about 1.8 to 3.6 nm in diameter and contains about 309 to about 2,057 metal atoms. This metal core has 1,10-phenanthroline organic moieties covalently attached to the metal core. A process for making this palladium and platinum cluster compound is also disclosed.
REFERENCES:
patent: 4124524 (1978-11-01), Danielmeyer et al.
patent: 4313734 (1982-02-01), Leuvering
patent: 5116759 (1992-05-01), Klainer et al.
"A Novel Giant Palladium Cluster" by Michail N. Vargaftik, Victor P. Zagorodnikov, Igor P. Stolyarov, IIya I. Moiseev, Vladimir A. Likholobov, Dmitry I. Kochubey, Andrew L. Chuvilin, Vladimir I. Zaikovsky, Kirill I. Zamaraev, and Galina I. Timofeeva, J. Chem. Soc., Chem. Commun., 1985.
"Nanogold .TM.-FAB'Access Nuclear Protein", NanoNews Newsletter, Winter, 1992, Issue No. 1.
"Colloidal Gold for Multiple Staining" by J. Doerr Schott, pp. 155-157, in Colloidal Gold, Principles, Methods and Applications, Academic Press (1989).
"FITC-Protein A-Gold Complex for Light and Electron Microscopic Immunocytochemistry", by Jurgen roth, Moise Bendayan, Lelio Orci, J. of Histochemistry 28: 55-57 (1980).
"Wheat Germ Agglutinin-apoHRP Gold: A New Retrograde Tracer for Light---and Electron-Microscope Single---and Double-Label Studies", by A.I. Basbaum and D. Menetrey, the Journal of Comparative Neurology 261: 306-318 (1987).
"Probing Microtubule-Dependent Intracellular Motility with Nanometre Particle Video Ultramicroscopy (Nanovid Ultramicroscopy)", by M. DeBrabander, G. Geuens, R. Nuydens, M. Moeremans and J. DeMey, Cytobios 43 273-283 (1985).
"A 1.4nm Gold Cluster Covalently Attached to Antibodies Improves Immunolabeling", by James F. Hainfeld and Frederic R. Furuya, The Journal of Histochemistry and Cytochemistry, vol. 40, No. 2, pp. 177-184, 1992.
"Synthesis of Thiol-derivatised Gold Nanoparticles in a Two-Phase Liquid-Liquid System", by M. Brust,M. Walker, D. Bethell, D. Schiffrin, R. Whyman, J. Chem. Soc., Chem. Comm., 1994, pp. 801-802.
"Labeling Update", Product Review, Nature, vol. 356, Mar. 12, 1992, p. 177.
"Products from NANOPROBES" Catalog 1993, pp. 1-12.
"Immunology: Pick of the Week", Product Review, Nature, vol. 353, Oct. 17, 1991, p. 680.
"Large Clusters and Colloids. Metals in the Embryonic State", by Gunter Schmid, Chemical Reviews, 1992, pp. 1709-1726.
"Ligand-Stabilized Giant Palladium Clusters: Promising Candidates in Heterogenous Catalysis" by Gunter Schmid, J. Am. Chem. Soc. 1993, 115, 2046-2048.
"EPR on the High-Nuclearity Palladium Cluster Pd.sub.561 Phen.sub.36 O.sub.200 ", J. de Aguiar, H.B. Brom. L.J. deJongh & G. Schimd, Z. Phys. D--Atoms, Molecules & Clusters 12, 457-459 (1989).
"Fresnel Effect in High Resolution Tem Imaging of Small Particles", V. Radmilovic & M.A. O'Keefe, Proc. 53rd Annual Meeting, Micros. Soc. Amer.; pp. 564-565, New York, 1995.
"Pt.sub.309 Phen.sub.36 O.sub.30.+-.10, a four-Shell Platinum Cluster", G. Schimd, B. Morun, J. Malm, Anew. Chem. Int. Ed. Engl. 28 (1989) No. 6, pp. 778-780.
Achutamurthy Ponnathapura
Nanoprobes, Inc.
Park Hankyel T.
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