Small molecule stimulators of neuronal growth

Details Small molecule stimulators of neuronal growth Small molecule stimulators of neuronal growth

2005-05-26

2009-12-29

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S054000, C514S061000, C514S062000, C536S055100, C536S055200

Reexamination Certificate

active

07638503

ABSTRACT:
Provided herein are small molecule stimulators of neuronal growth, their preparation, and their use for treatment of neurological disorders. In one embodiment, provided herein are methods of treatment, prevention, or amelioration of a variety of medical conditions associated with neurological disorders using the compounds and compositions provided herein.

REFERENCES:
patent: 6680304 (2004-01-01), Vila Pahi et al.
patent: WO03/002125 (2003-09-01), None
Sandson et al., The Potential Application of cyclo-oxygenase type 2 inhibitors to Alzheimer's disease: Expert Opinion on Investigational Drugs, (1998) vol. 7, No. 4, pp. 519-526.
Takagaki et al., “Domain Structure of Chondroitin SUlfate E Octasaccharides Binding to Type V Collagen,” Journal of Biological Chemistry (2002) vol. 277, No. 11, pp. 8882-8889.
Green, T. W., and Wits, P. G., Protective Groups in Organic Synthesis, (1999) Published by John Wiley and Sons, pp. 67-74.
Sugahara et al., “Structural Studies on the chondroitinase ABC-resistant sulfated tetrasaccharides isolated from various chondroitin sulfate isomers” Carbohydrate research (1994) vol. 255, pp. 145-163.
Garrett and Grisham, “Biochemistry” Published 1999 by Saunders College Publishers, p. 236.
Bradbury et al., “Chondroitinase ABC promotes function recovery after spinal cord injury,” Nature (2002) 416:636-640.
Brittis et al., “Chondroitin sulfate as a regulator of neuronal patterning in the retina,” Science (1992) 255:733-736.
Dou et al., “Differential effects of glycosaminoglycans on neurite growth on laminin and L1 substrates,” J. Neurosci. (1995) 15:8053-8066.
Emerling and Lander, “Inhibitors and promoters of thalamic neuron adhesion and outgrowth in embryonic neocortex: functional association with chondroitin sulfate,” Neuron (1996) 17:1089-1100.
Kalovidouris et al., “A role for fucose α (1-2) galactose carbohydrates in neuronal growth,” J. Am. Chem. Soc. (2005) 127:1340-1341.
Mizuguchi et al., “Chondroitin proteoglycans are involved in cell division of Caenohabditis elegans,” Nature (2003) 423:443-448.
Nadanaka et al., “Characteristic hexasaccharide sequences in octasaccharides derived from shark cartilage chondroitin sulfate D with a neurite outgrowth promoting activity,” J. Biol. Chem. (1998) 273:3296-3307.
Sugahara et al., “Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate,” Curr. Opin. Chem. Biol. (2003) 13:612-620.
Tsuchida et al., “Appican, the proteoglycan form of the amyloid precursor protein, contains chondroitin sulfate E in the repeating disaccharide region and 4-O-sulfated galactose in the linkage region,” J. Biol. Chem. (2001) 276:37155-37160.
Belot et al., “Unexpected stereochemical outcome of activated 4,6-O-benzylidene derivatives of the 2- deoxy-2-trichloroacetamido-D-galacto series in glycosylation reactions during the synthesis of a chondroitin 6-sulfate trisaccharide methyl glycoside,” Carb. Res. (2000) 325:93-106.
Blatter et al., “The use of 2-deoxy-2-trichloroacetamido-D-glucopyranose derivatives in synthesis of oligosaccharides,” Carb. Res. (1994) 260:189-202.
Jacquinet, “Synthesis of the methyl glycosides of the repeating units of chondroitin 4- nad 6-sulfate,” Carb. Res. (1990) 199:153-181.
Karst and Jacquinet, “Chemical synthesis of β-D-GlcpA(2SO4)-(1->3)-D-GalpNAc(6SO4), the disaccharide repeating unit of shark cartilage chondroitin sulfate D, and of its methyl β-D-glycoside derivative,” J. Chem. Soc. Perkin Trans (2000) 1:2709-2717.
Karst and Jacquinet, “Stereocontrolled total syntheses of shark cartilage chondroitin sulfate D-related tetra- and hexasaccharide methyl glycosides,” Eur. J. Org. Chem. (2002) 815-825.
Lucas et al., “Synthesis of heparin-like pentamers containing “opened” uronic acid moieties,” Tetrahedron (1990) 46:8207-8228.
Marra et al., “Synthesis of disaccharide fragments of dermatan sulfate,” Carb. Res. (1989) 195:39-50.
Tamura et al., “Synthetic approach towards sulfated chondroitin di-, tri- and tetrasaccharides corresponding to the repeating unit,” Carb. Res. (1998) 305:43-63.
Tamura et al., “A regio- and stereoselective synthesis of 4-O-sulfated chondroitin di- and tetrasaccharides based on the strategy designed for the elongation of the repeating unit,” Bioorg. Medic. Chem. Lett. (1995) 5:1351-1354.
Tully, et al., “A chondroitin sulfate small molecule that stimulates neuronal growth,” J. Am. Chem. Soc. (2004) 126:7736-7737.
Zhang and Magnusson, “DDQ-mediated oxidation of 4,6-O-methoxybenzylidene-protected saccharides in the presence of various nucleophiles: formation of 4-OH, 6-C1, and 6-Br derivatives,” J. Org. Chem. (1996) 61:2394-2400.
Falshaw et al., “Comparison of the glycosaminoglycans isolated from the skin and head cartilage of Gould's arrow squid (Nototodarus gouldi),” Carbohydrate Polymers (2000) 41:357-364.
Iyer et al., “Design and synthesis of hyaluronan-mimetic Gemini disaccharides,” Tetrahedron (2003) 59:631-638.
Koshiishi et al., “Analysis of chondroitin sulfate/dermatan sulfate chains in rat peritoneal resident macrophages,” J. Biol. Pharm. Bull. (1993) 16:307-308.

Affiliated with

Also associated with

Rating

Small molecule stimulators of neuronal growth does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Small molecule stimulators of neuronal growth, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Small molecule stimulators of neuronal growth will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4122821