Small molecule printing

Details Small molecule printing Small molecule printing

2011-04-26

2011-04-26

Steele, Amber D. (Department: 1639)

Combinatorial chemistry technology: method, library, apparatus

Library, per se

Library containing only organic compounds

C506S009000, C506S027000, C506S035000, C436S169000, C436S501000, C436S518000, C436S809000

Reexamination Certificate

active

07932213

ABSTRACT:
The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. A composition is provided that comprises an array of chemical compounds attached to a solid support, wherein the density of the array of compounds is at least 1000 spots per cm2. The inventive arrays are generated by: providing a solid support functionalized with a selected chemical moiety capable of interacting with a chemical compound to form an attachment and delivering compounds to the solid support having a density of at least 1000 spots per cm2. The present invention also provides methods for utilizing these arrays to identify small molecule partners for biological macromolecules of interest.

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